Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.


Our lab has been focused on the immunological synapse (figure, below) and integrating this into the 3D tissue context.

We have modeled this interaction by replacing the antigen presenting cell with a supported planar bilayer. Bilayers presenting MHC-peptide complexes and ICAM-1 to trigger a minimal immunological synapse.

This is an optically ideal system in which to visualize the supramolecular activation clusters. We have also applied this system to investigation of regulatory T cell defects in rheumatoid arthritis. Intravital microscopy has been a critical technology to understand how T cells interact with antigen presenting cells in vivoStudies in T cell zones, germinal centers, meninges and splenic red pulp have provided novel insights.

In the future, we will address how the immunological synapse contributes to tolerance and immunity using tools of systems biology and super-resolution imaging.

We will continue to use intravital microscopy to probe inflammatory mechanisms (see movie, below). A major focus will be the targeting therapies to the immunological synapse to cure chronic inflammatory diseases like rheumatoid arthritis.






The Immune Synapse

Edited by Professors Michael Dustin and Cosima T. Baldari, this new book includes useful cutting-edge methods and protocols for people in the field.

Related research themes