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Tissue remodelling and repair

Network of blood vessels

The overarching aim of the tissue biology theme is to understand how tissues respond to injury and how the inflammatory response it creates drives tissue remodelling and regeneration. We examine the molecular and cellular mechanisms that drive healthy tissue repair and explore how these become unbalanced in disease. A major component of this work takes place within the Versus Arthritis Centre for Osteoarthritis Pathogenesis and aims to understand the pathways that regulate cartilage wear and repair in joints. However, our research is also relevant for understanding many other processes, including fibrosis and fibrotic disorders, tumour growth and progression, wound and fracture repair and application of stem cell technologies.



Groups within this theme

Primary research goal is the identification and characterisation of the mechanisms of mechanobiology controlling the immune response in health and disease. Our objectives involve the application and development of novel ultrasensitive live-cell microscopy techniques with the right spatiotemporal sensitivity as demanded by the biology. Long-term goal of our research is the translation of our expertise and methodologies in mechanobiology to mechanomedicine in diagnostics and treatment of patients.
Fritzsche Group | Biophysical Immunology
We aim to understand the mechanisms behind uncontrolled cell migration - which promotes progression of certain conditions - to develop new treatments to prevent this progression.
Itoh Group | Cell Migration
Our group investigates how the extracellular matrix - the component of tissue that lies immediately outside and between cells - contributes to inflammation.
Midwood Group | Matrix Immunology
Monaco Group | Cardiovascular Inflammation
Monaco Group | Cardiovascular Inflammation
Nanchahal Group | Treating fibrosis and improving tissue regeneration
Nanchahal Group | Treating fibrosis and improving tissue regeneration
Our research focuses on all aspects of osteoarthritis, from understanding its causes to developing new treatments for the condition to improve people's quality of life.
Vincent Group | Molecular Pathogenesis of Osteoarthritis
Cells use unique spaces to organise the messaging that modifies their behaviour and respond to their environment. Our research looks at how one such space - the primary cilium - affects the way cells respond to external cues including mechanical force and inflammatory cytokines.
Wann Group | Primary Cilia in Musculoskeletal Health and Disease

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