Data science
The Data Science platform provides the Kennedy Institute with internationally competitive capabilities for computational biology research. It supports research activity in data management, computational genomics, statistical genetics, metagenomics, computational and mathematical biology, and clinical trials. These studies are conducted by specialist computational biology research groups, as well as by research groups working in other areas who incorporate computational approaches into their analyses.
Research is supported by an in-house single cell and spatial genomics facility, access to a state-of-the-art high-performance research computing cluster and dedicated infrastructure to manage, curate and mine patient data.
Co-leads
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Stephen Sansom
Associate Professor
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Brian Marsden
Associate Professor, Research Informatics; Associate Head of Medical Sciences Division - Digital and Information
KEY COLLABORATORS
The Data Science platform underpins the Kennedy Institute research activities in multiple areas and closely interacts with all the other Institute platforms. It also provides collaborative support for computational projects within and outside the Kennedy Institute.
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Lada Koneva
Research Associate in Bioinformatics
Key publications
A blood atlas of COVID-19 defines hallmarks of disease severity and specificity.
Journal article
COvid-19 Multi-omics Blood ATlas (COMBAT) Consortium. Electronic address: julian.knight@well.ox.ac.uk None. and COvid-19 Multi-omics Blood ATlas (COMBAT) Consortium None., (2022), Cell, 185, 916 - 938.e58
Secondary influenza challenge triggers resident memory B cell migration and rapid relocation to boost antibody secretion at infected sites.
Journal article
MacLean AJ. et al, (2022), Immunity, 55, 718 - 733.e8
IL-1-driven stromal-neutrophil interactions define a subset of patients with inflammatory bowel disease that does not respond to therapies.
Journal article
Friedrich M. et al, (2021), Nat Med, 27, 1970 - 1981
Genome-wide analysis of 53,400 people with irritable bowel syndrome highlights shared genetic pathways with mood and anxiety disorders
Journal article
JOSTINS-DEAN L. et al, (2021), Nature Genetics
Distinct transcription factor networks control neutrophil-driven inflammation.
Journal article
Khoyratty TE. et al, (2021), Nat Immunol, 22, 1093 - 1106
Deconvolution of monocyte responses in inflammatory bowel disease reveals an IL-1 cytokine network that regulates IL-23 in genetic and acquired IL-10 resistance.
Journal article
Aschenbrenner D. et al, (2020), Gut
SARS-CoV-2 antibody prevalence, titres and neutralising activity in an antenatal cohort, United Kingdom, 14 April to 15 June 2020.
Journal article
Lumley SF. et al, (2020), Euro Surveill, 25
Distinct fibroblast subsets drive inflammation and damage in arthritis.
Journal article
Croft AP. et al, (2019), Nature, 570, 246 - 251