The Data Science platform provides the Kennedy Institute with internationally competitive capabilities for computational biology research. It supports research activity in data management, computational genomics, statistical genetics, metagenomics, computational and mathematical biology, and clinical trials. These studies are conducted by specialist computational biology research groups, as well as by research groups working in other areas who incorporate computational approaches into their analyses.
Research is supported by an in-house single cell and spatial genomics facility, access to a state-of-the-art high-performance research computing cluster and dedicated infrastructure to manage, curate and mine patient data.
Associate Professor, Research Informatics; Associate Head of Medical Sciences Division - Digital and Information
The Data Science platform underpins the Kennedy Institute research activities in multiple areas and closely interacts with all the other Institute platforms. It also provides collaborative support for computational projects within and outside the Kennedy Institute.
A blood atlas of COVID-19 defines hallmarks of disease severity and specificity.
COvid-19 Multi-omics Blood ATlas (COMBAT) Consortium. Electronic address: email@example.com None. and COvid-19 Multi-omics Blood ATlas (COMBAT) Consortium None., (2022), Cell, 185, 916 - 938.e58
Secondary influenza challenge triggers resident memory B cell migration and rapid relocation to boost antibody secretion at infected sites.
MacLean AJ. et al, (2022), Immunity, 55, 718 - 733.e8
IL-1-driven stromal-neutrophil interactions define a subset of patients with inflammatory bowel disease that does not respond to therapies.
Friedrich M. et al, (2021), Nat Med, 27, 1970 - 1981
Genome-wide analysis of 53,400 people with irritable bowel syndrome highlights shared genetic pathways with mood and anxiety disorders
JOSTINS-DEAN L. et al, (2021), Nature Genetics
Distinct transcription factor networks control neutrophil-driven inflammation.
Khoyratty TE. et al, (2021), Nat Immunol, 22, 1093 - 1106
Deconvolution of monocyte responses in inflammatory bowel disease reveals an IL-1 cytokine network that regulates IL-23 in genetic and acquired IL-10 resistance.
Aschenbrenner D. et al, (2020), Gut
SARS-CoV-2 antibody prevalence, titres and neutralising activity in an antenatal cohort, United Kingdom, 14 April to 15 June 2020.
Lumley SF. et al, (2020), Euro Surveill, 25
Distinct fibroblast subsets drive inflammation and damage in arthritis.
Croft AP. et al, (2019), Nature, 570, 246 - 251
Small research facilities