Dendrou Group | Immune Disease Multiomics
- Kennedy
Our research aims to compare inflammatory diseases and immunological responses across tissues, over time and upon perturbation for translational benefit, leveraging multiomic technologies.
We investigate molecular circuits and cellular mechanisms across tissues and diseases to identify ‘hubs’ that may be targeted therapeutically via drug repositioning approaches and to provide insights for patient stratification and drug positioning strategies. We interrogate the relationship between variation in cell responsiveness and transcriptional kinetics and the spectrum of immune-related diseases spanning malignancies, autoimmunity and infections, as well as immune-relevant contexts including vaccination and transplantation to help inform therapeutic design.
We encourage team diversity and inclusivity and we are also highly collaborative – working with experimental and computational scientists and clinicians in academia and industry locally and internationally.
KEY RESEARCH AREAS OF THE GROUP
Genetics and Precision Genome Editing
- Investigating the architecture of genetic predisposition across immune-mediated diseases to explore the functional relevance and potential clinical utility of such cross-comparisons
- Precision genome editing with tandem autologous transplantation as a therapy for multiple severe immune-mediated diseases
Cellular and Spatial Computational/ML Analysis of Adult Immune Diseases
- Longitudinal profiling of immune disease patient pathophysiology before and after treatment, e.g. the TAURUS study
- Cross-tissue and cross-disease comparisons of pathophysiology via the Oxford-Johnson & Johnson Cartography Consortium
Spatiotemporal Mapping of Paediatric Inflammatory Diseases
- Childhood Therapeutic Atlas Partnership (CTAP) for spatiotemporal profiling of paediatric inflammatory bowel disease
- MAP-JAG
Investigating Temporal Vaccine Responses at High Resolution
- Mapping human inflammatory responses in ethnically diverse groups using a novel ex vivo lymph node model (https://chanzuckerberg.com/science/programs-resources/single-cell-biology/inflammation-projects/mapping-human-inflammatory-responses-in-ethnically-diverse-groups/)
- The Lymph nodE single-cell Genomics AnCestrY (LEGACY) Network: contextualizing the vaccine response of lymph nodes through the creation of an ancestrally diverse single-cell atlas
Interrogating T-cell Biology to Improve Blood Cancer Treatment
- Investigation of antigens targeted by T-cells mediating graft-versus-leukaemia and graft-versus-host disease following stem cell transplantation to help improve blood cancer treatment
The Dendrou group would like to gratefully acknowledge past and present support by the Wellcome Trust, Royal Society, UKRI Medical Research Council, the Rosetrees Trust, Nimbus Therapeutics, BBSRC, the Kennedy Trust, the NIHR Oxford Biomedical Research Centre, Cancer Research UK, the Chan Zuckerberg Initiative, and Johnson & Johnson Innovative Medicine.
Our team
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Calliope Dendrou
ASSOCIATE PROFESSOR
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Devika Agarwal
Senior Bioinformatician
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Jacqueline Siu
Wellcome Trust Early Career Fellow in Immunology
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Sarah Davidson
Postdoctoral Researcher
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Nadia Fernandes
Bioinformatician in Spatial Transcriptomics and Single-Cell Genomics
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Wencheng Yin
Senior Bioinformatician in Immune Single-Cell Omics & Machine Learning
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Giulia Garcia
DPhil Student
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Robin Mae Schreiner
DPhil Student
