The Cell Dynamics Platform provides access to advanced technologies to visualise and quantify the dynamics of cellular responses across scales – from single molecules in cells, to cellular activation in tissues and cellular networks in tissues across health and disease.
The platform includes state-of-the-art Mass Cytometry, Flow Cytometry and Advanced Microscopy. The Advanced Microscopy Facility includes the Oxford-Zeiss Centre of Excellence featuring two inverted LSM980 Confocal Microscopes with AiryScan detectors, and two upright LSM880 microscopes for ex vivo and in vivo tissue imaging. Advanced imaging also offers custom systems for imaging at interfaces (TIRF-SIM) and large area light sheet microscopy. The Cell Dynamics Platform is integrated with the Data Science platform through the Single Cell and Spatial Genomics facility and the Tissue Biology Platform through the Zeiss Connect equipped Fluorescence Slide Scanner.
Associate Professor (Innovation Investigator Track) and Rosalind Franklin Kennedy Trust Research Fellow
- University of Oxford Department of Oncology on Flow Cytometry (BD Aria III, completed) and Light Sheet Microscopy (Miltenyi Light Sheet Microscope, ongoing).
- Carl Zeiss, AG, with active discussions to push the limits of lattice light sheet and confocal microscopy technology.
Secondary influenza challenge triggers resident memory B cell migration and rapid relocation to boost antibody secretion at infected sites.
MacLean AJ. et al, (2022), Immunity, 55, 718 - 733.e8
A blood atlas of COVID-19 defines hallmarks of disease severity and specificity.
COvid-19 Multi-omics Blood ATlas (COMBAT) Consortium. Electronic address: email@example.com None. and COvid-19 Multi-omics Blood ATlas (COMBAT) Consortium None., (2022), Cell, 185, 916 - 938.e58
T-cell trans-synaptic vesicles are distinct and carry greater effector content than constitutive extracellular vesicles.
Céspedes PF. et al, (2022), Nat Commun, 13
Two-dimensional TIRF-SIM-traction force microscopy (2D TIRF-SIM-TFM).
Barbieri L. et al, (2021), Nat Commun, 12
Supramolecular attack particles are autonomous killing entities released from cytotoxic T cells.
Bálint Š. et al, (2020), Science, 368, 897 - 901
Small research facilities
Carl Ziess logo (awaiting picture)
Rosalind Franklin Institute logo (awaiting picture)