1. About Us

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    We are a world leading Institute focussing on identification of the causes and development of cures for chronic inflammatory diseases

  2. Research

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    Multidisciplinary research in immunology, inflammation and translational medicine

  3. Prize Studentships

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    Prize Studentships available within the Kennedy Institute

  4. Positions available

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    Opportunities to work within the Institute are regularly available

  5. Translational Medicine

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    The Institute seeks to translate basic science to the clinic

  6. OA Centre

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    The Centre aims to develop novel disease "markers" and therapies for patients with osteoarthritis and to create a national training resource for scientists and clinicians working within the OA field.

  7. Talks & Events

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    The Institute hosts regular seminars and events

  8. Contact us

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    The Institute is based on the Old Road Campus in Headington, Oxford

About the Institute

The Kennedy Institute is situated at the heart of the University of Oxford’s Old Road campus, a premier site for translational research in Oxford. The Institute houses basic and clinician scientists working in the areas of microbiome, immunology, inflammation and tissue biology and repair. We adopt a multidisciplinary approach, from basic biology, through models of disease to the development and testing of novel therapies in the clinic. There are strong links with clinical centres focussing on joint and bone diseases, inflammatory bowel disease and cancer. The Institute Director is Professor Fiona Powrie FRS.

News Highlights

Researchers at the Kennedy Institute, part of NDORMS have repurposed the approved drug miglustat to successfully slow the progression of multiple myeloma.
By changing mouse genes to block a protein associated with obesity, researchers at the Kennedy Institute of Rheumatology, NDORMS have prevented fat from forming around the animals' internal organs, even when the animals eat an unhealthy diet. The study in Nature Medicine found that these genetically engineered mice also retained their sensitivity to insulin (normally blunted by obesity), despite gaining weight.
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Events

Date: 23 Jun 2015 to 24 Jun 2015
Venue: Pembroke College, Pembroke Square, Oxford
OX1 1DW

Status: Registration open

OA Centre


The Centre aims to develop novel disease "markers" and therapies for patients with osteoarthritis and to create a national training resource for scientists and clinicians working within the OA field.

Notable Recent Publications

Polarized release of T-cell-receptor-enriched microvesicles at the immunological synapse. Choudhuri K, Llodra J, Roth EW, Tsai J, Gordo S, Wucherpfennig KW, Kam LC, Stokes DL, Dustin ML. Nature 2014; 507:118-23

The alarmin IL-33 promotes regulatory T-cell function in the intestine. Schiering C, Krausgruber T, Chomka A, Frohlich A, Adelmann K, Wohlfert EA, Pott J, Griseri T, Bollrath J, Hegazy AN, Harrison OJ, Owens BM, Lohning M, Belkaid Y, Fallon PG, Powrie F. Nature 2014; 513:564-8

Selective tumor necrosis factor receptor I blockade is antiinflammatory and reveals immunoregulatory role of tumor necrosis factor receptor II in collagen-induced arthritis. McCann FE, Perocheau DP, Ruspi G, Blazek K, Davies ML, Feldmann M, Dean JL, Stoop AA, Williams RO. Arthritis Rheumatol 2014; 66:2728-38

IRF5:RelA interaction targets inflammatory genes in macrophages. Saliba DG, Heger A, Eames HL, Oikonomopoulos S, Teixeira A, Blazek K, Androulidaki A, Wong D, Goh FG, Weiss M, Byrne A, Pasparakis M, Ragoussis J, Udalova IA. Cell Rep 2014; 8:1308-17

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