1. About Us


    We are a world leading Institute focussing on identification of the causes and development of cures for chronic inflammatory diseases

  2. Research


    Multidisciplinary research in immunology, inflammation and translational medicine

  3. Prize Studentships


    Prize Studentships available within the Kennedy Institute

  4. Positions available


    Opportunities to work within the Institute are regularly available

  5. Translational Medicine


    The Institute seeks to translate basic science to the clinic

  6. OA Centre


    The Centre aims to develop novel disease "markers" and therapies for patients with osteoarthritis and to create a national training resource for scientists and clinicians working within the OA field.

  7. Talks & Events


    The Institute hosts regular seminars and events

  8. Contact us


    The Institute is based on the Old Road Campus in Headington, Oxford

About the Institute

The Kennedy Institute is situated at the heart of the University of Oxford’s Old Road campus, a premier site for translational research in Oxford. The Institute houses basic and clinician scientists working in the areas of microbiome, immunology, inflammation and tissue biology and repair. We adopt a multidisciplinary approach, from basic biology, through models of disease to the development and testing of novel therapies in the clinic. There are strong links with clinical centres focussing on joint and bone diseases, inflammatory bowel disease and cancer. The Institute Director is Professor Fiona Powrie FRS.

News Highlights

A new study led by researchers at the Kennedy Institute and published today in Immunity [LINK] sheds light on the drivers behind Inflammatory bowel disease (IBD) and suggests potential new targets for treatment of the condition.
People in Oxford who have osteoarthritis of the knee are being invited to take part in a national charity-funded clinical trial to find a more effective treatment.


Date: 02 Sep 2015 to 04 Sep 2015
Venue: Natural History Museum, Oxford
Status: Registration open

OA Centre

The Centre aims to develop novel disease "markers" and therapies for patients with osteoarthritis and to create a national training resource for scientists and clinicians working within the OA field.

Notable Recent Publications

Granulocyte macrophage colony-stimulating factor-activated eosinophils promote interleukin-23 driven chronic colitis. Griseri T, Arnold IC, Pearson C, Krausgruber T, Schiering C, Franchini F, Schulthess J, McKenzie BS, Crocker PR, Powrie F. Immunity 2015; 43: 187-199

A mouse model of HIES reveals pro- and anti-inflammatory functions of STAT3. Steward-Tharp SM, Laurence A, Kanno Y, Kotlyar A, Villarino AV, Sciume G, Kuchen S, Resch W, Wohlfert EA, Jiang K, Hirahara K, Vahedi G, Sun HW, Feigenbaum L, Milner JD, Holland SM, Casellas R, Powrie F, O'Shea JJ. Blood 2014; 123:2978-2987

IRF5:RelA interaction targets inflammatory genes in macrophages. Saliba DG, Heger A, Eames HL, Oikonomopoulos S, Teixeira A, Blazek K, Androulidaki A, Wong D, Goh FG, Weiss M, Byrne A, Pasparakis M, Ragoussis J, Udalova IA. Cell Rep 2014; 8:1308-17

Selective tumor necrosis factor receptor I blockade is antiinflammatory and reveals immunoregulatory role of tumor necrosis factor receptor II in collagen-induced arthritis. McCann FE, Perocheau DP, Ruspi G, Blazek K, Davies ML, Feldmann M, Dean JL, Stoop AA, Williams RO. Arthritis Rheumatol 2014; 66:2728-38

The alarmin IL-33 promotes regulatory T-cell function in the intestine. Schiering C, Krausgruber T, Chomka A, Frohlich A, Adelmann K, Wohlfert EA, Pott J, Griseri T, Bollrath J, Hegazy AN, Harrison OJ, Owens BM, Lohning M, Belkaid Y, Fallon PG, Powrie F. Nature 2014; 513:564-8

Polarized release of T-cell-receptor-enriched microvesicles at the immunological synapse. Choudhuri K, Llodra J, Roth EW, Tsai J, Gordo S, Wucherpfennig KW, Kam LC, Stokes DL, Dustin ML. Nature 2014; 507:118-23


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