Talks & Events
About the Institute
The Kennedy Institute is situated at the heart of the University of Oxford’s Old Road campus, a premier site for translational research in Oxford. The Institute houses basic and clinician scientists working in the areas of microbiome, immunology, inflammation and tissue biology and repair. We adopt a multidisciplinary approach, from basic biology, through models of disease to the development and testing of novel therapies in the clinic. There are strong links with clinical centres focussing on joint and bone diseases, inflammatory bowel disease and cancer. The Institute Director is Professor Fiona Powrie FRS.
Notable Recent Publications
IRF5 controls both acute and chronic inflammation. Weiss M, Byrne AJ, Blazek K, Saliba DG, Pease JE, Perocheau D, Feldmann M, Udalova IA. Proc Natl Acad Sci U S A 2015
Granulocyte macrophage colony-stimulating factor-activated eosinophils promote interleukin-23 driven chronic colitis. Griseri T, Arnold IC, Pearson C, Krausgruber T, Schiering C, Franchini F, Schulthess J, McKenzie BS, Crocker PR, Powrie F. Immunity 2015; 43: 187-199
A mouse model of HIES reveals pro- and anti-inflammatory functions of STAT3. Steward-Tharp SM, Laurence A, Kanno Y, Kotlyar A, Villarino AV, Sciume G, Kuchen S, Resch W, Wohlfert EA, Jiang K, Hirahara K, Vahedi G, Sun HW, Feigenbaum L, Milner JD, Holland SM, Casellas R, Powrie F, O'Shea JJ. Blood 2014;
IRF5:RelA interaction targets inflammatory genes in macrophages. Saliba DG, Heger A, Eames HL, Oikonomopoulos S, Teixeira A, Blazek K, Androulidaki A, Wong D, Goh FG, Weiss M, Byrne A, Pasparakis M, Ragoussis J, Udalova IA. Cell Rep 2014; 8:1308-17
The alarmin IL-33 promotes regulatory T-cell function in the intestine. Schiering C, Krausgruber T, Chomka A, Frohlich A, Adelmann K, Wohlfert EA, Pott J, Griseri T, Bollrath J, Hegazy AN, Harrison OJ, Owens BM, Lohning M, Belkaid Y, Fallon PG, Powrie F. Nature 2014; 513:564-8
Polarized release of T-cell-receptor-enriched microvesicles at the immunological synapse. Choudhuri K, Llodra J, Roth EW, Tsai J, Gordo S, Wucherpfennig KW, Kam LC, Stokes DL, Dustin ML. Nature 2014; 507:118-23
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