Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.



OA CENTRE

OA Centre tile

Our Arthritis Research UK Centre of Excellence aims to develop new treatments for arthritis, improving healthcare and transforming people's lives.



research highlights

Powrieelifepaper

ILC3S ORCHESTRATE GUT INFLAMMATION

Innate lymphoid cells (ILC) accumulate in the inflamed intestine in inflammatory bowel disease (IBD), but how this relatively sparse population of cells could promote dramatic inflammation in the gut has been unclear. The Powrie Lab show in Elife that group 3 ILC produce the inflammatory cytokine GM-CSF that recruits additional inflammatory cell types to exacerbate IBD. Full paper


Monacogroup

IDO ENZIME PROTECTS IN ATHEROSCLEROSIS 

The enzyme indoleamine-2,3-dioxygenase (IDO) catalyses degradation of the essential amino acid tryptophan into immunomodulatory metabolites. The Monaco lab report in PNAS that IDO metabolites stimulate B cell interleukin-10 production and are protective in atherosclerosis. Full paper