Inflammation is a crucial process that helps protect against infection and promote tissue repair after injury. Inflammatory responses are usually short lived. If inflammation fails to subside, however, it can contribute to the development of a wide range of chronic diseases, including rheumatoid arthritis, cardiovascular disease, inflammatory bowel disease, and certain types of cancer. We investigate inflammatory cell types – and their functional plasticity – and the complex positive and negative feedback loops controlling initiation, progression and resolution of the response. In particular, single cell genomic and proteomic approaches are used to define signalling and regulatory pathways that underpin the behaviour of diseased tissue. Our research provides basic insight into the disease process and reveals strategies for development of new biomarkers or therapies.