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Tissue remodelling and regeneration

An overarching aim is to appreciate how tissues respond to injury and how the inflammatory response this elicits drives tissue remodelling and regeneration. We examine the molecular and cellular mechanisms that drive healthy tissue repair and dissect how these activities become unbalanced in disease. A major component of this work takes place within the Centre for Osteoarthritis Pathogenesis and aims to understand the pathways that regulate cartilage wear and repair in joints. However, our research is also relevant for understanding many other processes, including fibrosis and fibrotic disorders, tumour growth and progression, wound and fracture repair and application of stem cell technologies.



Groups within this theme

We aim to understand the mechanisms behind uncontrolled cell migration - which promotes progression of certain conditions - to develop new treatments to prevent this progression.
Itoh Group | Cell Migration
We examine the role and therapeutic potential of vascular niches and their angiocrine signals in normal and tumor tissues
Kusumbe Group | Tissue and Tumor Microenvironments
Lim Group | Molecular Imaging Group
Lim Group | Molecular Imaging Group
Our group investigates how the extracellular matrix - the component of tissue that lies immediately outside and between cells - contributes to inflammation.
Midwood Group | Matrix Immunology
We are interested in how the cartilage lining our bone ends works.
Murphy Group | Cartilage Biology and Repair
Nanchahal Group | Treating fibrosis and improving tissue regeneration
Nanchahal Group | Treating fibrosis and improving tissue regeneration
We research what increases and decreases loss of cartilage in osteoarthritis, to improve treatment solutions for the condition.
Troeberg Group | Metalloprotease Regulation
Our research focuses on all aspects of osteoarthritis, from understanding its causes to developing new treatments for the condition to improve people's quality of life.
Vincent Group | Molecular Pathogenesis of Osteoarthritis
Cells use unique spaces to organise the messaging that modifies their behaviour and respond to their environment. Our research looks at how one such space - the primary cilium - affects the way cells respond to inflammation.
Wann Group | Primary Cilia in Inflammatory Signalling