Clinical translation is essential to fulfil the Institute's mission to use its discovery research to help in the development, testing and delivery of new therapies and treatments to address disease. Using both well-established and new patient groups, researchers at the Institute perform translational research and experimental medicine studies to discover and test new therapeutic targets and biomarkers, in diseases such as inflammatory arthritis, osteoarthritis, inflammatory bowel disease, fibrosis and certain types of cancer. As part of this approach researchers use immune phenotyping and multiomic technologies to understand disease at the point that it starts, as it progresses, and in response to therapy at both the molecular and cellular level.
Clinical translation is delivered through studies within individual research groups, and by a number of strategic programmes such as the Arthritis Therapy Acceleration Programme (A-TAP), the Centre for Osteoarthritis Pathogenesis Versus Arthritis, ORBIT Eye Network and the NIHR Oxford BRC. Clinical translation takes place in close collaboration with nearby research centres and clinical sites including the Botnar Research Centre, Nuffield Orthopaedic Centre and Translational Gastroenterology Unit, as well as other partner sites, including the Institute of Inflammation and Ageing at the University of Birmingham.