Contact information
Research groups
Linyi Zhu
Ph.D.
Senior Research Fellow
I have a multidisciplinary research background. After BSc in Pharmacy and PhD in Physical Chemistry, I took a post-doctoral position in Oxford at Kennedy Institute of Rheumatology from 2015.
My postdoc research projects focus on finding new targets and treatments for osteoarthritis. During my postdoc period, I discovered retinoic acid metabolism blocking agents as potential disease-modifying drugs for osteoarthritis; performed the first single-nuclei RNA sequencing in normal porcine cartilage; and observed the suppression of shear-induced genes in murine knee joints under the treatment of a novel lubricant.
Other Activities
Guest Editor
Frontiers in Molecular Biosciences
Frontiers in Cell and Developmental Biology
REVIEW EDITOR
Frontiers in Cell and Developmental Biology
Peer Reviewer
Scientific Report
Frontiers in Cell and Developmental Biology
International Journal of Molecular Sciences
Nutrients
Symmetry
Arthritis Research & Therapy
Pharmaceutics
Pharmaceuticals
Military medical research
Medicina
Cells
Journal of Orthopaedic Surgery and Research
Grant reviewer
UK Research and Innovation
Recent publications
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Variants in ALDH1A2 reveal an anti-inflammatory role for retinoic acid and a new class of disease-modifying drugs in osteoarthritis.
Zhu L. et al, (2022), Sci Transl Med, 14
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MAINTAINING ALL-TRANS RETINOIC ACID LEVELS WITH TALAROZOLE SUPPRESSES MECHANFLAMMATION FOLLOWING CARTILAGE INJURY THROUGH A PERIXOSOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA-DEPENDENT MECHANISM
Kamalathevan P. et al, (2022), OSTEOARTHRITIS AND CARTILAGE, 30, S181 - S181
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SINGLE NUCLEI RNA-SEQUENCING OF PORCINE ARTICULAR CARTILAGE UNCOVERS THE CHONDROCYTES CLUSTERS THAT CHANGE IN RESPONSE TO MECHANICAL INJURY
Zhu L. et al, (2022), OSTEOARTHRITIS AND CARTILAGE, 30, S27 - S27
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TALAROZOLE, A RETINOIC ACID METABOLISM BLOCKING AGENT, SUPPRESSES MECHANOFLAMMATION AND ATTENUATES THE DEVELOPMENT OF POST-TRAUMATIC OA
Zhu L. et al, (2022), OSTEOARTHRITIS AND CARTILAGE, 30, S72 - S73
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Highly efficient CRISPR-Cas9-mediated editing identifies novel mechanosensitive microRNA-140 targets in primary human articular chondrocytes.
Chaudhry N. et al, (2022), Osteoarthritis Cartilage