Liposomic lubricants suppress acute inflammatory gene regulation in the joint in vivo.
Zhu L. et al, (2025), Acta Biomater
Variants in ALDH1A2 reveal an anti-inflammatory role for retinoic acid and a new class of disease-modifying drugs in osteoarthritis.
Zhu L. et al, (2022), Sci Transl Med, 14
MAINTAINING ALL-TRANS RETINOIC ACID LEVELS WITH TALAROZOLE SUPPRESSES MECHANFLAMMATION FOLLOWING CARTILAGE INJURY THROUGH A PERIXOSOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA-DEPENDENT MECHANISM
Kamalathevan P. et al, (2022), OSTEOARTHRITIS AND CARTILAGE, 30, S181 - S181
SINGLE NUCLEI RNA-SEQUENCING OF PORCINE ARTICULAR CARTILAGE UNCOVERS THE CHONDROCYTES CLUSTERS THAT CHANGE IN RESPONSE TO MECHANICAL INJURY
Zhu L. et al, (2022), OSTEOARTHRITIS AND CARTILAGE, 30, S27 - S27
TALAROZOLE, A RETINOIC ACID METABOLISM BLOCKING AGENT, SUPPRESSES MECHANOFLAMMATION AND ATTENUATES THE DEVELOPMENT OF POST-TRAUMATIC OA
Zhu L. et al, (2022), OSTEOARTHRITIS AND CARTILAGE, 30, S72 - S73
Highly efficient CRISPR-Cas9-mediated editing identifies novel mechanosensitive microRNA-140 targets in primary human articular chondrocytes.
Chaudhry N. et al, (2022), Osteoarthritis Cartilage
Murine joint destabilisation induces shear-responsive gene expression in the superficial cartilage which can be modified by a phospholipid-based lubricant
Zhu L. et al, (2021), INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, 102, A5 - A6
The ciliary protein IFT88 controls post-natal cartilage thickness and influences development of osteoarthritis.
Coveney CR. et al, (2021), Arthritis Rheumatol
INTRA-ARTICULAR INJECTION OF PHOSPHOLIPID-BASED LUBRICANT REDUCES SHEAR-RESPONSIVE INFLAMMATORY GENES IN THE SUPERFICIAL LAYER OF CARTILAGE POST MURINE JOINT DESTABILISATION
Zhu L. et al, (2021), OSTEOARTHRITIS AND CARTILAGE, 29, S172 - S172
RESTORING REDOX BALANCE IN CARTILAGE FOLLOWING INJURY RESTORES RETINOIC ACID LEVELS AND PREVENTS MECHANOFLAMMATION
Kamalathevan P. et al, (2021), OSTEOARTHRITIS AND CARTILAGE, 29, S36 - S37
RNA-SEQ ANALYSIS OF HAND OSTEOARTHRITIS CARTILAGE REVEALS A RECIPROCAL REGULATION BETWEEN RETINOIC ACID AND MARKERS OF CELL SENESCENCE, IDENTIFYING TALAROZOLE AS A NOVEL TARGETING STRATEGY IN HAND OSTEOARTHRITIS
Zhu L. et al, (2021), OSTEOARTHRITIS AND CARTILAGE, 29, S308 - S308
THE CILIARY PROTEIN INTRAFLAGELLAR TRANSPORT 88 IS REQUIRED FOR THE MATURATION, HOMEOSTASIS AND MECHANOADAPTATION OF ARTICULAR CARTILAGE
Coveney CR. et al, (2021), OSTEOARTHRITIS AND CARTILAGE, 29, S26 - S27
TNF alpha-stimulated gene 6 (TSG-6) is weakly chondroprotective in murine OA but does not account for FGF2-mediated joint protection
Zhu L. et al, (2021), INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, 102, 134 - 134
TSG-6 Is Weakly Chondroprotective in Murine OA but Does not Account for FGF2-Mediated Joint Protection.
Zhu L. et al, (2020), ACR Open Rheumatol, 2, 605 - 615
TNF ALPHA-STIMULATED GENE 6 (TSG6) IS CHONDROPROTECTIVE IN VIVO BUT OVEREXPRESSION CANNOT COMPENSATE FOR LOSS OF FGF2
Zhu L. et al, (2020), OSTEOARTHRITIS AND CARTILAGE, 28, S107 - S108
Targeting retinoic acid metabolism as an anti-inflammatory treatment for hand osteoarthritis
Zhu L. et al, (2019), INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, 100, A31 - A32
Functional Characterization of the Osteoarthritis Genetic Risk Residing at ALDH1A2 Identifies rs12915901 as a Key Target Variant.
Shepherd C. et al, (2018), Arthritis Rheumatol, 70, 1577 - 1587
RETINOIC ACID IS REGULATED BY CARTILAGE INJURY AND IS ANTI-INFLAMMATORY IN HAND OSTEOARTHRITIS
Zhu L. et al, (2018), ANNALS OF THE RHEUMATIC DISEASES, 77, 179 - 180