We are a world-leading basic and translational inflammatory sciences centre.
The three major themes of our research - immunity and microbiome, inflammation biology and tissue remodelling and repair - are relevant for a diverse range of chronic inflammatory disorders, including arthritis, inflammatory bowel disease, tissue fibrosis and certain types of cancer.
We apply state-of-the-art technologies in analysis of disease models and patient tissue samples to understand why disease develops and to reveal new diagnostic markers and targets for therapy.
Strategic partnerships with nearby clinical centres such as the Nuffield Orthopaedic Centre and the John Radcliffe Hospital facilitate scientific translation from bench to bedside.
Durable Interactions of T Cells with T Cell Receptor Stimuli in the Absence of a Stable Immunological Synapse.
Mayya V. et al, (2018), Cell Rep, 22, 340 - 349
Clarke AJ. et al, (2018), J Exp Med, 215, 399 - 413
Mapping tenascin-C interaction with toll-like receptor 4 reveals a new subset of endogenous inflammatory triggers.
Zuliani-Alvarez L. et al, (2017), Nat Commun, 8
A Large Polysaccharide Produced by Helicobacter hepaticus Induces an Anti-inflammatory Gene Signature in Macrophages.
Danne C. et al, (2017), Cell Host Microbe, 22, 733 - 745.e5