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New therapeutic targets identified to treat inflammatory bowel disease

Millions of patients with ulcerative colitis or Crohn’s disease, collectively known as inflammatory bowel disease (IBD), are given fresh hope as a new study shows why some of them do not respond to current treatments.

Fiona Powrie appointed new Deputy Chair of Wellcome’s Board of Governors

Fiona Powrie, Director of the Kennedy Institute of Rheumatology at the University of Oxford has been selected as the next Deputy Chair of Wellcome’s Board of Governors.

Large genetic study suggests shared biological processes cause irritable bowel syndrome and anxiety

An international study of more than 50,000 people with irritable bowel syndrome (IBS) has revealed that IBS symptoms may be caused by the same biological processes as conditions such as anxiety. The research highlights the close relationship between brain and gut health and paves the way for development of new treatments.

Two researchers working, one pointing at the the computer screen

Unlocking the secrets of the microbiome

Jethro Johnson, Deputy Director of the Oxford Centre for Microbiome Studies explains how the centre is building a research community to understand the microbiome and harness its power to promote health and prevent disease.

Labelling proteins through the diet gives new insights into how collagen-rich tissues change as we age

A new study, published in eLife, uses advanced tissue analysis technology to show how the incorporation of new proteins changes in bone and cartilage with age.

Into the future: watching biology unfold

As part of the University of Oxford’s mission to provide its researchers with the newest state-of-the-art optical imaging equipment and as part of a strategic partnership with the Kennedy Institute of Rheumatology (KIR), the Institute of Developmental and Regenerative Medicine (IDRM), and Carl Zeiss AG (ZEISS), ZEISS has installed a ZEISS Lattice Lightsheet 7 microscope at the KIR.

The front entrance to the Kennedy Institute

The Kennedy Institute completes its roof extension

Building work at the Kennedy Institute of Rheumatology has finished, providing a new third floor that houses additional meeting and collaboration space for data science and offices for the management of clinical trials.

A world-leading medical research centre where discovery research drives the development of transformative therapies for chronic inflammatory and degenerative disease.

240 Staff, students and academic visitors

30 Nationalities

£99M+ in Research Income

Select Publications

IL-1-driven stromal-neutrophil interactions define a subset of patients with inflammatory bowel disease that does not respond to therapies.

Friedrich M. et al, (2021), Nat Med

Latest news

Professor Chris Buckley joins the Kennedy Institute as Director of Clinical Research

12 January 2022

Behind enemy lines: research finds a new ally in the fight against cardiovascular disease hidden within the vessel wall itself

11 January 2022

Confocal imaging of antigen-induced arthritis in mouse knee. Image taken by Kristina Zec

COVID-19 research

COVID-19 research at the Kennedy Institute

Find out more about Covid research

New therapeutic targets identified to treat inflammatory bowel disease

Fiona Powrie appointed new Deputy Chair of Wellcome’s Board of Governors

Large genetic study suggests shared biological processes cause irritable bowel syndrome and anxiety

Unlocking the secrets of the microbiome

Labelling proteins through the diet gives new insights into how collagen-rich tissues change as we age

Into the future: watching biology unfold

The Kennedy Institute completes its roof extension

Kennedy Institute of Rheumatology

A world-leading medical research centre where discovery research drives the development of transformative therapies for chronic inflammatory and degenerative disease.

Select Publications

IL-1-driven stromal-neutrophil interactions define a subset of patients with inflammatory bowel disease that does not respond to therapies.

Age-dependent changes in protein incorporation into collagen-rich tissues of mice by in vivo pulsed SILAC labelling.

Distinct transcription factor networks control neutrophil-driven inflammation.

TBK1 and IKKε act like an OFF switch to limit NLRP3 inflammasome pathway activation

Astigmatic traction force microscopy (aTFM).

Latest news

Professor Chris Buckley joins the Kennedy Institute as Director of Clinical Research

Behind enemy lines: research finds a new ally in the fight against cardiovascular disease hidden within the vessel wall itself

New Oxford-Zeiss Centre of Excellence opens at the University of Oxford

HOPE-c opens up for recruitment

Fiona Powrie honoured by British Society for Immunology

COVID-19 research

COVID-19 research at the Kennedy Institute

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