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Our Arthritis Research UK Centre of Excellence aims to develop new treatments for arthritis, improving healthcare and transforming people's lives.



immunological synapse explained

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research highlights

IlottISME

DRIVERS OF DYSBIOSIS IN COLITIS

In a paper published in ISME, the Powrie Lab use combined metagenomic and metatranscriptomic sequencing to profile the gut microbiota in colitis. They find increased abundance and transcription of microbial gene families involved in oxidative stress resistance, rare nutrient uptake and defence against antimicrobial peptides. These findings suggest that in colitis environmental stressors in the inflamed gut drive dysbiosis. Full paper


Monacogroup

IDO ENZYME PROTECTS IN ATHEROSCLEROSIS 

The enzyme indoleamine-2,3-dioxygenase (IDO) catalyses degradation of the essential amino acid tryptophan into immunomodulatory metabolites. The Monaco lab report in PNAS that IDO metabolites stimulate B cell interleukin-10 production and are protective in atherosclerosis. Full paper