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OA centre

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Our Arthritis Research UK Centre of Excellence aims to develop new treatments for arthritis, improving healthcare and transforming people's lives.



research highlights

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IRF5 REGULATES ALLERGIC AIRWAY INFLAMMATION

The pulmonary immune system protects the host from infection but also drives chronic allergic diseases such as asthma.  The Udalova lab show in Mucosal Immunology that transcription factor IRF5 promotes effective responses to inhaled antigen and that IRF5-deficient macrophages drive airway hyperreactivity. Read full paper.


Midwood

INJURY-INDUCED MACROPHAGE TLR4 RESPONSES

Both bacterial LPS and tissue damage-associated Tenascin-C activate TLR4 signalling in macrophages. The Midwood lab show in Science Signaling that although these ligands activate some common pathways, LPS-stimulated macrophages are biased toward matrix destruction whereas tenascin-C-stimulated macrophage synthesise matrix components.  Read full paper.