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OA centre

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Our Arthritis Research UK Centre of Excellence aims to develop new treatments for arthritis, improving healthcare and transforming people's lives.



research highlights

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DYNAMICS OF MACROPHAGE ACTIVATING AND INHIBITORY RECEPTOR NANOCLUSTERS

Macrophages contribute to host defence through the uptake – or so called phagocytosis – of pathogens and other harmful foreign particles. In the JCB, the Davis and Dustin labs use super resolution microscopy to show how activating and inhibitory receptors are reorganised at a nanometer scale to integrate positive and negative signals for proper regulation of the macrophage phagocytic response.  Read full paper.


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IRF5 REGULATES ALLERGIC AIRWAY INFLAMMATION

The pulmonary immune system protects the host from infection but also drives chronic allergic diseases such as asthma.  The Udalova lab show in Mucosal Immunology that transcription factor IRF5 promotes effective responses to inhaled antigen and that IRF5-deficient macrophages drive airway hyperreactivity. Read full paper.