Live imaging shows surprising passage of T cells in the spleen
Research from Tal Arnon’s group at the Kennedy Institute reveals a network of perivascular pathways that guide T cells into the spleen.
Read moreThe NDORMS response to COVID-19
A number of members of the department are actively helping with the response to the COVID pandemic. Playing a key role in research, literature reviews, clinical trials and engineering projects, all have a shared commitment to collaborate globally to tackle the pandemic.
Read moreNew weapon identified in arsenal against disease
Researchers in the Dustin Group reveal supramolecular attack particles are autonomous killing entities released from cytotoxic T lymphocytes
Read moreNDORMS professor awarded prestigious Carol Nachman prize for Rheumatology
Christopher Buckley, Kennedy Professor of Translational Rheumatology at the University of Oxford and Birmingham, has been awarded the 2020 Carol Nachman prize for Rheumatology.
Read moreOxford leads part of major COVID-19 drugs trial
The Arthritis Therapy Acceleration Programme (A-TAP), led by the Kennedy Institute in Oxford and the Institute of Inflammation and Ageing in Birmingham, provides support for the new CATALYST Trial to investigate whether administering the anti-inflammatory drug infliximab to patients with COVID-19 can prevent progression to respiratory failure or death.
Read moreNew atlas of stromal cells maps out potential for treating human fibrosis
Research at the Kennedy Institute reveals sub-populations of stromal cells with distinct functions in human fibrotic disease. These findings could inform development of more specific therapies with fewer off-target effects.
Read moreKennedy Institute of Rheumatology
A world-leading medical research centre where discovery research drives the development of transformative therapies for chronic inflammatory and degenerative disease.
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Select Publications
IL-33 promotes anemia during chronic inflammation by inhibiting differentiation of erythroid progenitors.
Swann JW. et al, (2020), J Exp Med, 217
Cellular census of human fibrosis defines functionally distinct stromal cell types and states.
Layton TB. et al, (2020), Nat Commun, 11
The interleukin 22 pathway interacts with mutant KRAS to promote poor prognosis in colon cancer.
McCuaig S. et al, (2020), Clin Cancer Res
IRF5 guides monocytes toward an inflammatory CD11c+ macrophage phenotype and promotes intestinal inflammation.
Corbin AL. et al, (2020), Sci Immunol, 5
Supramolecular attack particles are autonomous killing entities released from cytotoxic T cells.
Balint Š. et al, (2020), Science