CD2 corolla calls T cells to arms
A team from the University of Oxford has visualised how key cells of the immune system lock onto cancerous or infected cells to destroy them. The work was led by the Mike Dustin’s group at the Kennedy Institute of Rheumatology and experts in colorectal and ovarian cancers from across Oxford and computational biologists at the University of Birmingham.
Read moreKennedy Institute of Rheumatology
A world-leading medical research centre where discovery research drives the development of transformative therapies for chronic inflammatory and degenerative disease.
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Select Publications
A dynamic CD2-rich compartment at the outer edge of the immunological synapse boosts and integrates signals.
Demetriou P. et al, (2020), Nat Immunol, 21, 1232 - 1243
The Interleukin 22 Pathway Interacts with Mutant KRAS to Promote Poor Prognosis in Colon Cancer.
McCuaig S. et al, (2020), Clin Cancer Res
IL-33 promotes anemia during chronic inflammation by inhibiting differentiation of erythroid progenitors.
Swann JW. et al, (2020), J Exp Med, 217
Identifying collagen VI as a target of fibrotic diseases regulated by CREBBP/EP300.
Williams LM. et al, (2020), Proc Natl Acad Sci U S A, 117, 20753 - 20763
Cellular census of human fibrosis defines functionally distinct stromal cell types and states.
Layton TB. et al, (2020), Nat Commun, 11
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