Kennedy Institute of Rheumatology
We are a world-leading basic and translational inflammatory sciences centre. The three major themes of our research - immunity and microbiome, inflammation biology and tissue remodelling and repair - are relevant for a diverse range of chronic inflammatory disorders, including arthritis, inflammatory bowel disease, tissue fibrosis and certain types of cancer. We apply state-of-the-art technologies in analysis of disease models and patient tissue samples to understand why disease develops and to reveal new diagnostic markers and targets for therapy. Strategic partnerships with nearby clinical centres such as the Nuffield Orthopaedic Centre and the John Radcliffe Hospital facilitate scientific translation from bench to bedside.
Sterile signals generate weaker and delayed macrophage NLRP3 inflammasome responses relative to microbial signals.
Bezbradica JS. et al, (2017), Cell Mol Immunol, 14, 118 - 126
Krausgruber T. et al, (2016), Nat Commun, 7
Byrne AJ. et al, (2016), Mucosal Immunol
Distinct microenvironmental cues stimulate divergent TLR4-mediated signaling pathways in macrophages.
Piccinini AM. et al, (2016), Sci Signal, 9
Targeted IL-4 therapy synergizes with dexamethasone to induce a state of tolerance by promoting Treg cells and macrophages in mice with arthritis.
Kawalkowska JZ. et al, (2016), Eur J Immunol, 46, 1246 - 1257
Our Arthritis Research UK Centre of Excellence aims to develop new treatments for arthritis, improving healthcare and transforming people's lives.
DYNAMICS OF MACROPHAGE ACTIVATING AND INHIBITORY RECEPTOR NANOCLUSTERS
Macrophages contribute to host defence through the uptake – or so called phagocytosis – of pathogens and other harmful foreign particles. In the JCB, the Davis and Dustin labs use super resolution microscopy to show how activating and inhibitory receptors are reorganised at a nanometer scale to integrate positive and negative signals for proper regulation of the macrophage phagocytic response. Read full paper.
IRF5 REGULATES ALLERGIC AIRWAY INFLAMMATION
The pulmonary immune system protects the host from infection but also drives chronic allergic diseases such as asthma. The Udalova lab show in Mucosal Immunology that transcription factor IRF5 promotes effective responses to inhaled antigen and that IRF5-deficient macrophages drive airway hyperreactivity. Read full paper.