Research groups
Yoshi Itoh
Associate Professor and Principal Investigator Cell Migration Group
After receiving his Msc in Pharmaceutical Sciences from Tokyo College of Pharmacy in Japan, in 1991 Dr Itoh moved to the University of Kansas Medical Center, USA to work with Prof Hideaki Nagase.
Using his research outcomes, he received a PhD from Tokyo University of Pharmacy and Life Sciences, Japan in 1996. In 1997 he became an Assistant Professor in Prof Motoharu Seiki's department at the Institute of Medical Sciences, University of Tokyo.
In 2001 he then moved to the Kennedy Institute of Rheumatology, Imperial College London to run his own lab and relocated to Oxford when the Kennedy Institute joined the University of Oxford.
His major scientific interests have been centred on mechanisms of cellular invasion and tissue destruction, especially in the aspects of arthritis and cancer as they share common mechanisms and pathways.
Key publications
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Selective Inhibition of Membrane Type 1 Matrix Metalloproteinase Abrogates Progression of Experimental Inflammatory Arthritis: Synergy With Tumor Necrosis Factor Blockade.
Journal article
Kaneko K. et al, (2016), Arthritis Rheumatol, 68, 521 - 531
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Detection of cartilage matrix degradation by autofluorescence lifetime.
Journal article
Manning HB. et al, (2013), Matrix Biol, 32, 32 - 38
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Basal localization of MT1-MMP is essential for epithelial cell morphogenesis in 3D collagen matrix.
Journal article
Weaver SA. et al, (2014), J Cell Sci, 127, 1203 - 1213
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ADAM10 controls collagen signaling and cell migration on collagen by shedding the ectodomain of discoidin domain receptor 1 (DDR1).
Journal article
Shitomi Y. et al, (2015), Mol Biol Cell, 26, 659 - 673
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Discoidin domain receptor 2 mediates collagen-induced activation of membrane-type 1 matrix metalloproteinase in human fibroblasts.
Journal article
Majkowska I. et al, (2017), J Biol Chem, 292, 6633 - 6643
Recent publications
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Roles of Toll-like Receptor Signaling in Inflammatory Bone Resorption
Journal article
Tominari T. et al, (2024), Biology, 13, 692 - 692
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Assembly of neuron- and radial glial-cell-derived extracellular matrix molecules promotes radial migration of developing cortical neurons
Journal article
Mubuchi A. et al, (2024), eLife, 12
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Assembly of neuron- and radial glial cell-derived extracellular matrix molecules promotes radial migration of developing cortical neurons
Preprint
Mubuchi A. et al, (2024)
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The stiffness and collagen control differentiation of osteoclasts with an altered expression of c-Src in podosome
Journal article
Urano K. et al, (2024), Biochemical and Biophysical Research Communications, 149636 - 149636
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Investigation of MT1-MMP Activity in Cancer Cells.
Journal article
Itoh Y., (2024), Methods Mol Biol, 2747, 151 - 166