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Publications

Endosomal TLR3 signaling in stromal osteoblasts induces prostaglandin E2–mediated inflammatory periodontal bone resorption

Tominari T. et al, (2022), Journal of Biological Chemistry, 298, 101603 - 101603

Coordination of two kinesin superfamily motor proteins, KIF3A and KIF13A, is essential for pericellular matrix degradation by membrane-type 1 matrix metalloproteinase (MT1-MMP) in cancer cells.

Gifford V. et al, (2022), Matrix Biol

Alpha-2-Macroglobulin in Inflammation, Immunity and Infections

Vandooren J. and Itoh Y., (2021), Frontiers in Immunology, 12

Gram-positive bacteria cell wall-derived lipoteichoic acid induces inflammatory alveolar bone loss through prostaglandin E production in osteoblasts

Tominari T. et al, (2021), Scientific Reports, 11

Modulation of microenvironment signals by proteolytic shedding of cell surface ECM receptors

ITOH Y., (2021), Frontiers in Cell and Developmental Biology

A common SNP risk variant MT1-MMP causative for Dupuytren’s Disease has a specific defect in collagenolytic activity

ITOH Y. et al, (2021), Matrix Biology

Autofluorescence Lifetime Reports Cartilage Damage in Osteoarthritis.

Lagarto JL. et al, (2020), Sci Rep, 10

MT1-MMP-dependent cell migration: proteolytic and non-proteolytic mechanisms

Gifford V. and ITOH Y., (2019), Biochemical Society Transactions

Hypergravity and microgravity exhibited reversal effects on the bone and muscle mass in mice.

Tominari T. et al, (2019), Sci Rep, 9

Epithelial polarization in 3D matrix requires DDR1 signaling to regulate actomyosin contractility.

Søgaard PP. et al, (2019), Life Sci Alliance, 2

Design, synthesis and biological evaluation of bifunctional inhibitors of membrane type 1 matrix metalloproteinase (MT1-MMP).

Cuffaro D. et al, (2019), Bioorg Med Chem, 27, 196 - 207

Discoidin domain receptors: Microenvironment sensors that promote cellular migration and invasion

Itoh Y., (2018), Cell Adhesion & Migration, 1 - 8

Inhibition of LRP1 shedding reverses cartilage matrix degradation in osteoarthritis

Yamamoto K. et al, (2017), INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, 98, A3 - A3

Inhibition of Shedding of Low-Density Lipoprotein Receptor-Related Protein 1 Reverses Cartilage Matrix Degradation in Osteoarthritis.

Yamamoto K. et al, (2017), Arthritis Rheumatol, 69, 1246 - 1256

Discoidin domain receptor 2 mediates collagen-induced activation of membrane-type 1 matrix metalloproteinase in human fibroblasts.

Majkowska I. et al, (2017), J Biol Chem, 292, 6633 - 6643

Highly sensitive and adaptable fluorescence-quenched pair discloses the substrate specificity profiles in diverse protease families.

Poreba M. et al, (2017), Sci Rep, 7

Metalloproteinases in Rheumatoid Arthritis: Potential Therapeutic Targets to Improve Current Therapies.

Itoh Y., (2017), 148, 327 - 338

Development of a specific affinity-matured exosite inhibitor to MT1-MMP that efficiently inhibits tumor cell invasion in vitro and metastasis in vivo.

Botkjaer KA. et al, (2016), Oncotarget, 7, 16773 - 16792

Selective Inhibition of Membrane Type 1 Matrix Metalloproteinase Abrogates Progression of Experimental Inflammatory Arthritis: Synergy With Tumor Necrosis Factor Blockade.

Kaneko K. et al, (2016), Arthritis Rheumatol, 68, 521 - 531

Membrane-type matrix metalloproteinases: Their functions and regulations.

Itoh Y., (2015), Matrix Biol, 44-46, 207 - 223

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