Mathilde Pohin
Postdoctoral Research Scientist
Leukocytes -stromal interaction in IBD
After completing a PhD in cellular and molecular immunology in the University of Poitiers (France), I joined the Kennedy Institute of Rheumatology in November 2017.
My research aims to understand the function of stromal cells in IBD and how these cells interact with immune cells to sustain chronic inflammation. I am dissecting the cellular and molecular landscape of inflamed tissue from IBD patients with gene expression profiling, quantitative in situ analyses, multiplexed image fluorescence and functional ex vivo assays. I am also using in vivo mouse models of IBD to interrogate key pathways involved in IBD pathophysiology. and identify new therapeutic targets.
Recent publications
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Cross-tissue, single-cell stromal atlas identifies shared pathological fibroblast phenotypes in four chronic inflammatory diseases.
Journal article
Korsunsky I. et al, (2022), Med (N Y), 3, 481 - 518.e14
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IL-1-driven stromal-neutrophil interactions define a subset of patients with inflammatory bowel disease that does not respond to therapies.
Journal article
Friedrich M. et al, (2021), Nat Med, 27, 1970 - 1981
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Adipocyte autophagy limits gut inflammation by controlling oxylipin levels
Preprint
Richter FC. et al, (2021)
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Chronic Alcohol Consumption Exacerbates the Severity of Psoriasiform Dermatitis in Mice.
Journal article
Vasseur P. et al, (2020), Alcoholism, clinical and experimental research, 44, 1728 - 1733
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Cytokine Networks in the Pathophysiology of Inflammatory Bowel Disease.
Journal article
Friedrich M. et al, (2019), Immunity, 50, 992 - 1006