Isobel Leece
Postdoctoral Research Assistant in Immuno-Oncology
Immunologist interested in how immune pressure leads to spatiotemporal segregation and immune escape in cancers
Not all cancer cells are equal, and research in patients and in mice has described segregation of these tumours based on mutations in immune related genes. Experimentally, the degree of cancer segregation is explained by T cell pressure. My work is looking at whether tumour clones isolate themselves to escape the immune system, and how changes in the interferon signalling pathway determine the spatiotemporal dynamics of cancers.
My PhD focused on melanoma metastasis to the lymph nodes, with the goal of understanding whether cytotoxic cells in the lymph node were effectively killing. Experience with mouse models, spectral flow cytometry and multiplex immunohistochemistry.