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Publications

THE CILIARY PROTEIN INTRAFLAGELLAR TRANSPORT 88 IS REQUIRED FOR THE MATURATION, HOMEOSTASIS AND MECHANOADAPTATION OF ARTICULAR CARTILAGE

Coveney CR. et al, (2020), OSTEOARTHRITIS AND CARTILAGE, 28, S75 - S75

Regulation of the Extracellular Matrix by Ciliary Machinery.

Collins I. and Wann AKT., (2020), Cells, 9

IFT88 maintains profound influence in the post-natal joint, through joint maturation, and during adult homeostasis acting as the cartilage mechanoeffector

Coveney C. et al, (2019)

Mechanical loading inhibits cartilage inflammatory signalling via an HDAC6 and IFT-dependent mechanism regulating primary cilia elongation.

Fu S. et al, (2019), Osteoarthritis Cartilage, 27, 1064 - 1074

Mechanoadaptation: articular cartilage through thick and thin.

Vincent TL. and Wann AKT., (2019), J Physiol, 597, 1271 - 1281

Prominin-1 controls stem cell activation by orchestrating ciliary dynamics.

Singer D. et al, (2019), EMBO J, 38

Cilia protein IFT88 regulates extracellular protease activity by optimizing LRP-1-mediated endocytosis.

Coveney CR. et al, (2018), FASEB J

Chondrocyte expansion is associated with loss of primary cilia and disrupted hedgehog signalling.

Thompson CL. et al, (2017), Eur Cell Mater, 34, 128 - 141

IFT88 influences chondrocyte actin organization and biomechanics.

Wang Z. et al, (2016), Osteoarthritis Cartilage, 24, 544 - 554

Hedgehog signalling does not stimulate cartilage catabolism and is inhibited by Interleukin-1β.

Thompson CL. et al, (2015), Arthritis Res Ther, 17

The primary cilium influences interleukin-1β-induced NFκB signalling by regulating IKK activity.

Wann AKT. et al, (2014), Cell Signal, 26, 1735 - 1742

Are cellular mechanosensors potential therapeutic targets in osteoarthritis?

Drexler S. et al, (2014), International Journal of Clinical Rheumatology, 9, 155 - 167

Surface topography regulates wnt signaling through control of primary cilia structure in mesenchymal stem cells.

McMurray RJ. et al, (2013), Sci Rep, 3

Interleukin-1β sequesters hypoxia inducible factor 2α to the primary cilium.

Wann AK. et al, (2013), Cilia, 2

A role for IFT88/the primary cilium in the inflammatory response to interleukin-1

Wann AKT. and Knight MM., (2012), Cilia, 1

Primary cilia elongation in response to interleukin-1 mediates the inflammatory response.

Wann AKT. and Knight MM., (2012), Cell Mol Life Sci, 69, 2967 - 2977

Primary cilia mediate mechanotransduction through control of ATP-induced Ca2+ signaling in compressed chondrocytes.

Wann AKT. et al, (2012), FASEB J, 26, 1663 - 1671

The Role of the Primary Cilium in Chondrocyte Response to Mechanical Loading

Wann AKT. et al, (2012), Mechanically Gated Channels and their Regulation, 405 - 426

Eicosapentaenoic acid and docosahexaenoic acid reduce interleukin-1β-mediated cartilage degradation.

Wann AKT. et al, (2010), Arthritis Res Ther, 12

Signal pathways regulating hyaluronan secretion into static and cycled synovial joints of rabbits.

Ingram KR. et al, (2009), J Physiol, 587, 4361 - 4376

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