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High levels of interleukin 6 (IL 6/B cell stimulatory factor-2) were detected in synovial fluids from the joints of patients with active rheumatoid arthritis (RA). The cells found in freshly isolated synovial fluid constitutively expressed IL 6 mRNA. The synovial tissues obtained by joint biopsy were also found to produce IL 6 in vitro. Immunohistochemical analysis demonstrated that CD2+ T cells as well as CD20+ blastoid B cells in the synovial tissues produce IL 6. The data indicate that IL 6 is generated constitutively in RA and its overproduction may explain the local as well as the generalized symptoms of RA, since IL 6 can function as B cell growth and differentiation factor as well as hepatocyte-stimulating factor.

Original publication

DOI

10.1002/eji.1830181122

Type

Journal article

Journal

Eur J Immunol

Publication Date

11/1988

Volume

18

Pages

1797 - 1801

Keywords

Antigens, CD20, Antigens, Differentiation, B-Lymphocyte, Antigens, Differentiation, T-Lymphocyte, Arthritis, Rheumatoid, CD2 Antigens, Humans, Interleukin-6, Interleukins, RNA, Messenger, Receptors, Immunologic, Synovial Fluid, Synovial Membrane