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We recently showed that human thyroid epithelial cells, which are normally negative for HLA-DR molecules, express HLA-DR in thyroid autoimmunity. Furthermore, induction of HLA-DR on normal thyroid cells can be achieved by culture with plant lectins. We have now found that recombinant human interferon-gamma (IFN-gamma) induces expression of HLA-DR molecules on cultured human thyroid cells, whereas Namalva IFN-alpha, recombinant IFN-beta or recombinant interleukin-2 (IL-2) do not. All three IFN, but not IL-2, enhanced thyroid cell HLA-A,B,C expression. The results strongly implicate T cells (which are the source of IFN-gamma) in the aberrant induction of DR on thyroid epithelial cells which is proposed to be a central feature of the immunopathological processes leading to autoimmunity.


Journal article


Clin Exp Immunol

Publication Date





265 - 273


Cells, Cultured, Dose-Response Relationship, Drug, Epithelium, Fluorescent Antibody Technique, HLA Antigens, HLA-A Antigens, HLA-B Antigens, HLA-C Antigens, HLA-DR Antigens, Histocompatibility Antigens Class II, Humans, Interferon-gamma, Interleukin-2, Thyroid Gland