Curving out a new path: CD28/B7 cis interactions.
Zhou XMM., Mørch AM., Dustin ML.
Important signaling events at the immunological synapse have increasingly been linked to cis interactions between receptors on T cells. In this issue of Immunity, Zhao et al.1 implicate cis CD28/B7 interactions facilitated by curved membrane invaginations in boosting tumor immunity.