Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Researchers at the Kennedy Institute and the University of York develop a new imaging approach that offers superior resolution to track the movement of soluble proteins in tissues.

Soluble proteins help to correctly position immune cells in tissues and throughout the body to optimise immune defense. Up until now visualising the precise movement of these proteins has been tricky because different molecules of the same protein display variable patterns of diffusion. Profs Mark Coles, Mark Leake (University of York) and colleagues now report a new high-speed light microscopy approach that allows tracking of single molecules with multimodal mobility patterns.

Speaking of the work, Mark Coles said "By developing a novel imaging system to directly image how these chemoattractive molecules move in tissues we will be able to better understand how to target these molecules in rheumatological disease".

Then current study focuses on a certain type of proteins called chemokines that guide the migration of cells in tissues. But the authors suggest their imaging approach could be used to study many different signalling proteins and lipids that contribute to inflammatory and degenerative diseases.

Mark Coles is funded by the Kennedy Trust for Rheumatology Research and the research was supported by the Biological Physical Sciences Institute, the Medical Research Council, the Wellcome Trust and the Biotechnology and Biological Sciences Research Council.

Similar stories

Breakthrough in treatment for Dupuytren’s disease

Injection of the anti-TNF drug adalimumab into Dupuytren’s disease nodules is effective in reducing nodule hardness and nodule size.

New research suggests targeting blood vessels could be key to controlling fibrotic disease

By studying blood vessels at single cell resolution, Professor Jagdeep Nanchahal and colleagues found that in Dupuytren’s disease, a fibrotic disorder of the hand, the vasculature is key to orchestrating the development of human fibrosis.

Defining the role of resident memory B cells in the fight against influenza

Researchers at the Kennedy Institute of Rheumatology have used 3D and live-imaging to show how resident memory B cells boost antibodies to fight influenza.

A blood atlas of COVID-19 defines hallmarks of disease severity and specificity

The COVID-19 Multi-omic Blood Atlas (COMBAT) has identified blood hallmarks of COVID-19 involving particular immune cell populations and their development, components of innate and adaptive immunity, and connectivity with the inflammatory response.

Behind enemy lines: research finds a new ally in the fight against cardiovascular disease hidden within the vessel wall itself

A new study reveals the existence of a powerful ally in the fight against cardiovascular disease, a protective subset of vascular macrophages expressing the C-type lectin receptor CLEC4A2, a molecule which fosters "good" macrophage behaviour within the vessel wall.

A drug being trialled to treat cancer, could be the key to reducing gut inflammation

Published in Nature Communications, a new study reveals a new signalling pathway behind macrophage inflammatory activity