Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Researchers at the Kennedy Institute and the University of York develop a new imaging approach that offers superior resolution to track the movement of soluble proteins in tissues.

Soluble proteins help to correctly position immune cells in tissues and throughout the body to optimise immune defense. Up until now visualising the precise movement of these proteins has been tricky because different molecules of the same protein display variable patterns of diffusion. Profs Mark Coles, Mark Leake (University of York) and colleagues now report a new high-speed light microscopy approach that allows tracking of single molecules with multimodal mobility patterns.

Speaking of the work, Mark Coles said "By developing a novel imaging system to directly image how these chemoattractive molecules move in tissues we will be able to better understand how to target these molecules in rheumatological disease".

Then current study focuses on a certain type of proteins called chemokines that guide the migration of cells in tissues. But the authors suggest their imaging approach could be used to study many different signalling proteins and lipids that contribute to inflammatory and degenerative diseases.

Mark Coles is funded by the Kennedy Trust for Rheumatology Research and the research was supported by the Biological Physical Sciences Institute, the Medical Research Council, the Wellcome Trust and the Biotechnology and Biological Sciences Research Council.

Similar stories

Small mechanical forces in immune cells measured at unprecedented sensitivity

Research

Oxford researchers have used advanced microscopy techniques to measure previously unseen forces generated by cells during an immune response; a breakthrough for mechanobiology and future advances in health and disease.

Oxford to collaborate with Janssen to map the cellular landscape of immune mediated disorders

Research

The University of Oxford has entered into a strategic collaboration with Janssen Biotech, Inc., one of the Janssen Pharmaceutical Companies of Johnson & Johnson.

Vascular loss shown to be the primary hallmark of aging

Research

New Research from the Kusumbe group at the Kennedy Institute of Rheumatology identifies vascular attrition, marked by pericyte to fibroblast differentiation, as a primary hallmark of aging and highlights organ-specific vascular changes with age.

Immunology preprint reviews launched in Nature Reviews Immunology

Research

The Oxford-Mount Sinai (OxMS) Preprint Journal Club has partnered with Nature Reviews Immunology to launch a monthly Preprint Watch column.

Drug may boost vaccine responses in older adults

General Research

A preliminary study shows that a drug which helps immune cells self-clean may improve vaccine protection in older adults

Living reviews launched by Oxford and Cardiff in the wake of COVID-19 research

Research

In a combined effort to help COVID-19 researchers the University of Oxford and Cardiff University have launched a series of “living reviews” in Oxford University Press’s new open access journal “Oxford Open Immunology”.