4 September 2023
A new study looked at the effect of patient genetics on their response to secukinumab, an anti-IL17 therapy commonly used to treat inflammatory conditions including arthritis and psoriasis. No link was found between a patient’s genetic variants and their response to therapy. This study challenges the idea that genetics might significantly account for the variable responses to anti-IL17 therapy seen in the clinic.
27 June 2023
A new type of macrophages recently identified in atherosclerotic lesions could provide a missing link in understanding the inflammatory origins of the common yet fatal condition.
1 June 2023
A team led by Alex Clarke at the Kennedy Institute has identified how high mitochondrial activity regulates antibody responses crucial for immunity but is also necessary for the development of lymphoma.
24 May 2023
Insights into a specific macrophage population suggest that these cells could drive inflammation in rheumatoid arthritis. Understanding their complex role could lead to better treatments for patients.
19 November 2021
Published in Nature Communications, a new study reveals a new signalling pathway behind macrophage inflammatory activity
22 October 2021
Millions of patients with ulcerative colitis or Crohn’s disease, collectively known as inflammatory bowel disease (IBD), are given fresh hope as a new study shows why some of them do not respond to current treatments.
New drug class could offer a targeted safer treatment alternative for patients with rheumatoid arthritis
15 February 2019
A new treatment targeting tenascin-C could reduce the progression and severity of rheumatoid arthritis (RA) at the very early stages of disease.
12 February 2019
Researchers in Oxford have found that an individual’s immune system – and in particular the presence of T-cells amongst tumour cells – may play an important role in survival after surgery to remove pancreatic cancer.
6 July 2018
Scientists in the Kennedy Institute, NDORMS show anti-TNF inhibits the cells responsible for Dupuytren’s disease.
1 June 2018
Researchers at the Kennedy Institute and the University of York develop a new imaging approach that offers superior resolution to track the movement of soluble proteins in tissues.
9 January 2018
New research published in Cell Reports by the Dustin Group has discovered a new way for immune cells to relay information about infection or genetic mutations through dynamic, yet durable cell contacts before deciding how to respond.
20 December 2017
A recent publication from the Powrie group at the Kennedy Institute of Rheumatology has described a novel mechanism by which the commensal pathogen Heliobacter hepaticus maintains its niche in the intestinal environment.
Autophagy-dependent generation of free fatty acids is critical for normal neutrophil differentiation
20 September 2017
Recent research from the Simon Group has discovered an unexpected novel role that autophagy plays during the generation of neutrophils.
3 April 2017
A new study published today in Nature Medicine could change the lives of millions of people living with inflammatory bowel diseases (IBD) who don’t respond to the current standard of care.
9 August 2016
Two Kennedy Institute scientists have proposed a solution to a puzzle of the human immune system: how our immune system scales its response in proportion to any threat to our health to make it 'just right'. Their ideas, published in the journal Trends in Immunology, could support a range of medical research.
24 July 2015
A new study led by researchers at the Kennedy Institute and published today in Immunity sheds light on the drivers behind Inflammatory bowel disease (IBD) and suggests potential new targets for treatment of the condition.