Advanced Microscopy Team
Oxford-Zeiss Centre of excellence in Biomedical Imaging
|
Scientific Director Oxford -Zeiss Centre of Excellence in Biomedical Imaging |
Associate Professor Marco Fritzsche is the Scientific Director of the Oxford-Zeiss Centre of Excellence (Oxford-ZCoE) in Biomedical Imaging and leads the Biophysical Immunology Laboratory (www.bpi-oxford.com) between the Rosalind Franklin Institute and the Kennedy Institute for Rheumatology at the University of Oxford, UK. The BPI Laboratory aims to unravel the impact of biophysics and mechanobiology on the human immune response in health and disease. For this mission, the BPI lab develop custom-built microscopy technology at the interface of biophysics and immunology. |
|
Senior Advanced Microscopy Manager |
I am responsible for organizing the daily activities in the Oxford-ZCoE. This includes all aspects required in the operation of a well-functioning core facility including advising and training of users, maintenance and troubleshooting of the equipment, and advanced method development in collaboration with Centre users. Prior to joining the Oxford-ZCoE in 2021, I was the Facility Manager at the Wolfson Imaging Centre at the MRC Weatherall Institute of Molecular Medicine at the University of Oxford (since 2012). Throughout my career, I have extensive expertise in fluorescence microscopy hardware and image acquisition software, initially as an advanced research user and more recently as a Facility Manager and instructor in a multi-user core facility. This expertise includes hands-on experience with a variety of light microscopy configurations (wide-field, 1- and 2-photon confocal, spinning disc confocal, TIRF, STED, SIM, and light-sheet), specific microscopy techniques (e.g. FRAP, FCS, SPT, FLIM, and localization microscopy) and associated quantitative data analysis for a variety of biomedical applications. |
|
Advanced Image Analyst |
Accepting applications until 10th January 2022 |
Multiplex imaging
|
Lead Laboratory Technician in Multiplex Imaging |
I am the SRF Lead for the Cell DIVE multiplexing system which allows for the visualisation, identification and quantification of multiple markers on a single tissue sample. I am very interested in not only immunofluorescence microscopy but whole mount light sheet imaging and spatial omic techniques. |
TECHNOLOGY AND DEVELOPMENT
|
Postdoctoral Researcher |
I am an experimental physicist by training with a deep motivation in developing and exploring new advanced optical tools. Driven by the motivation to design and deliver advanced optical microscopy methods, I am currently building a lattice light sheet microscope coupled with structured illumination and adaptive optics in the Advanced Custom-Design Imaging Suite. |
|
|
I find a lot of joy in figuring out these new or little used technologies, then condensing the need-to-knows and how-tos such that they are accessible, and researchers can make the most of them. I am currently working on adapting the TIRF-SIM instrument to best meet user needs including implementation of astigmatic detection. I am also a superuser on the Zeiss Lattice Lightsheet 7 within the Oxford-ZCoE. |
|
DPhil. Student |
Currently, I am working on the development of a novel high-throughput fluorescence microscopy platform that can detect and track the ability of immune cells to kill pathogens within large cell ensembles at single-cell sensitivity. This technology has the potential to advance our understanding of the key mechanisms underlying the human immune response. |
