- Simon Group | Autophagy in the Immune System Research Group
I am interested in the role that autophagy has during the differentiation of hematopoietic stem cells. In particular, I am interested in how energy-metabolic adaption is linked to autophagy and its relevance during cellular differentiation.
Autophagy-Dependent Generation of Free Fatty Acids Is Critical for Normal Neutrophil Differentiation.
Riffelmacher T. et al, (2017), Immunity, 47, 466 - 480.e5
Autophagy dictates metabolism and differentiation of inflammatory immune cells.
Riffelmacher T. et al, (2017), Autophagy, 1 - 8
Mechanistic roles of autophagy in hematopoietic differentiation.
Riffelmacher T. and Simon A-K., (2017), FEBS J, 284, 1008 - 1020
The autophagy gene Atg16l1 differentially regulates Treg and TH2 cells to control intestinal inflammation.
Kabat AM. et al, (2016), Elife, 5
Autophagy limits proliferation and glycolytic metabolism in acute myeloid leukemia.
Watson AS. et al, (2015), Cell Death Discov, 1