Kim Midwood

• Screening for Novel Endogenous Inflammatory Stimuli Using the Secreted Embryonic Alkaline Phosphatase NF-κB Reporter Assay.

  Zuliani-Alvarez L. et al, (2017), Bio Protoc, 7

• Tenascin-C at a glance.

  Midwood KS. et al, (2016), J Cell Sci, 129, 4321 - 4327

• Identification of an immunodominant peptide from citrullinated tenascin-C as a major target for autoantibodies in rheumatoid arthritis.

  Schwenzer A. et al, (2016), Ann Rheum Dis, 75, 1876 - 1883

• Distinct microenvironmental cues stimulate divergent TLR4-mediated signaling pathways in macrophages.

  Piccinini AM. et al, (2016), Sci Signal, 9

• Tenascin C upregulates interleukin-6 expression in human cardiac myofibroblasts via toll-like receptor 4.

  Maqbool A. et al, (2016), World J Cardiol, 8, 340 - 350

• The extracellular matrix: A new dimension in disease diagnosis and treatment

  Aungier S. and Midwood K., (2016), Biochemist, 38, 10 - 15

• Investigating the Role of Toll-Like Receptors in Models of Arthritis.

  Piccinini AM. et al, (2016), 1390, 351 - 381

• Detection of antibodies to citrullinated tenascin-C in patients with early synovitis is associated with the development of rheumatoid arthritis.

  Raza K. et al, (2016), RMD Open, 2

• Potent anti-inflammatory effects of the narrow spectrum kinase inhibitor RV1088 on rheumatoid arthritis synovial membrane cells.

  To WS. et al, (2015), Br J Pharmacol, 172, 3805 - 3816

• Fibrinogen-Related Proteins in Tissue Repair: How a Unique Domain with a Common Structure Controls Diverse Aspects of Wound Healing.

  Zuliani-Alvarez L. and Midwood KS., (2015), Adv Wound Care (New Rochelle), 4, 273 - 285

• Tenascin-C: Form versus function.

  Giblin SP. and Midwood KS., (2015), Cell Adh Migr, 9, 48 - 82

• Tenascin-C: Exploitation and collateral damage in cancer management.

  Spenlé C. et al, (2015), Cell Adh Migr, 9, 141 - 153

• Special issue of Cell Adhesion & Migration on Tenascins: Defining their role in tissue homeostasis and cancer.

  Midwood K. and Orend G., (2015), Cell Adh Migr, 9, 1 - 3

• Advances in Toll-like receptor biology: Modes of activation by diverse stimuli.

  Bryant CE. et al, (2015), Crit Rev Biochem Mol Biol, 50, 359 - 379

• Tenascins in stem cell niches.

  Chiquet-Ehrismann R. et al, (2014), Matrix Biol, 37, 112 - 123

• Illustrating the interplay between the extracellular matrix and microRNAs.

  Piccinini AM. and Midwood KS., (2014), Int J Exp Pathol, 95, 158 - 180

• Unravelling the signalling pathways promoting fibrosis in dupuytren's disease reveals TNF as a therapeutic target

  Verjee LS. et al, (2014), BRITISH JOURNAL OF SURGERY, 101, 41 - 41

• The extracellular matrix and cancer: regulation of tumor cell biology by tenascin-C

  Orend G. et al, (2014)

• Isometric contraction of Dupuytren's myofibroblasts is inhibited by blocking intercellular junctions.

  Verhoekx JS. et al, (2013), J Invest Dermatol, 133, 2664 - 2671

• Tenascin-C and miR-155: how the extracellular matrix and the microRNA conspire to fight infectious disease

  Piccinini AM. and Midwood KS., (2013), INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, 94, A2 - A2

• Startups on the menu.

  Midwood K., (2013), Nat Biotechnol, 31

• Unraveling the signaling pathways promoting fibrosis in Dupuytren's disease reveals TNF as a therapeutic target.

  Verjee LS. et al, (2013), Proc Natl Acad Sci U S A, 110, E928 - E937

• Fibronectin assembly and function: A multi-dimensional view

  To WS. and Midwood KS., (2012), 71 - 123

• Raised circulating tenascin-C in rheumatoid arthritis.

  Page TH. et al, (2012), Arthritis Res Ther, 14

• Endogenous control of immunity against infection: tenascin-C regulates TLR4-mediated inflammation via microRNA-155.

  Piccinini AM. and Midwood KS., (2012), Cell Rep, 2, 914 - 926

• The alarmin IL-33 is a notch target in quiescent endothelial cells.

  Sundlisaeter E. et al, (2012), Am J Pathol, 181, 1099 - 1111

• Endogenous activation of adaptive immunity: tenascin-C drives interleukin-17 synthesis in murine arthritic joint disease.

  Ruhmann M. et al, (2012), Arthritis Rheum, 64, 2179 - 2190

• Targeting DAMP activation of Toll-like receptors: novel pathways to treat rheumatoid arthritis?

  Page T. and Midwood KS., (2012), Rheumatoid Arthritis - Treatment, 211 - 232

• Intrinsic danger: activation of Toll-like receptors in rheumatoid arthritis.

  Goh FG. and Midwood KS., (2012), Rheumatology (Oxford), 51, 7 - 23

• A role for tenascin-C in driving Th17 cell polarization in the RA joint?

  Ruhmann M. et al, (2011), IMMUNOLOGY, 135, 148 - 148

• NI-0101, a Therapeutic TLR4 Monoclonal Antibody for Rheumatoid Arthritis

  Elson G. et al, (2011), ARTHRITIS AND RHEUMATISM, 63, S383 - S383

• Advances in tenascin-C biology.

  Midwood KS. et al, (2011), Cell Mol Life Sci, 68, 3175 - 3199

• Plasma and cellular fibronectin: distinct and independent functions during tissue repair.

  To WS. and Midwood KS., (2011), Fibrogenesis Tissue Repair, 4

• Persistent expression of the pro-inflammatory extracellular matrix glycoprotein tenascin-C drives arthritic joint disease

  Piccinini AMP. et al, (2011), INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, 92, A30 - A30

• Identification of novel and distinct binding sites within tenascin-C for soluble and fibrillar fibronectin.

  To WS. and Midwood KS., (2011), J Biol Chem, 286, 14881 - 14891

• Toll-like receptor signaling: common pathways that drive cardiovascular disease and rheumatoid arthritis.

  Monaco C. et al, (2011), Arthritis Care Res (Hoboken), 63, 500 - 511

• DAMPENING INFLAMMATION BY MODULATING TLR SIGNALLING

  Midwood K., (2011), RHEUMATOLOGY, 50, 7 - 7

• MicroRNA epigenetics: a new avenue for wound healing research.

  Bavan L. et al, (2011), BioDrugs, 25, 27 - 41

• Expression and immune function of tenascin-C.

  Udalova IA. et al, (2011), Crit Rev Immunol, 31, 115 - 145

• Post-transcriptional regulation of alpha-smooth muscle actin determines the contractile phenotype of Dupuytren's nodular cells.

  Verjee LS. et al, (2010), J Cell Physiol, 224, 681 - 690

• Cryptic domains of tenascin-C differentially control fibronectin fibrillogenesis.

  To WS. and Midwood KS., (2010), Matrix Biol, 29, 573 - 585

• Proteolytic fragments of tenascin-C promote cartilage degradation

  Sofat N. et al, (2010), INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, 91, A47 - A48

• Transcriptional regulation of the endogenous danger signal tenascin-C: a novel autocrine loop in inflammation.

  Goh FG. et al, (2010), J Immunol, 184, 2655 - 2662

• DAMPening inflammation by modulating TLR signalling.

  Piccinini AM. and Midwood KS., (2010), Mediators Inflamm, 2010

• The role of tenascin-C in tissue injury and tumorigenesis.

  Midwood KS. and Orend G., (2009), J Cell Commun Signal, 3, 287 - 310

• Myofibroblast distribution in Dupuytren's cords: correlation with digital contracture.

  Verjee LS. et al, (2009), J Hand Surg Am, 34, 1785 - 1794

• Targeting Toll-like receptors in autoimmunity.

  Midwood KS. et al, (2009), Curr Drug Targets, 10, 1139 - 1155

• Tenascin-C is an endogenous activator of Toll-like receptor 4 that is essential for maintaining inflammation in arthritic joint disease.

  Midwood K. et al, (2009), Nat Med, 15, 774 - 780

• Tenascin-C regulates fibroblast migration within 3D fibrin-fibronectin matrices

  Trebaul A. et al, (2007), INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, 88, A93 - A93

• Regulation of fibroblast migration by tenascin-C.

  Trebaul A. et al, (2007), Biochem Soc Trans, 35, 695 - 697

• Modulation of cell-fibronectin matrix interactions during tissue repair.

  Midwood KS. et al, (2006), J Investig Dermatol Symp Proc, 11, 73 - 78

• Coregulation of fibronectin signaling and matrix contraction by tenascin-C and syndecan-4.

  Midwood KS. et al, (2004), Mol Biol Cell, 15, 5670 - 5677

• Self-assembled monolayers of alpha,omega-diphosphonic acids on Ti enable complete or spatially controlled surface derivatization.

  Danahy MP. et al, (2004), Langmuir, 20, 5333 - 5337

• Easy and efficient bonding of biomolecules to an oxide surface of silicon.

  Midwood KS. et al, (2004), Langmuir, 20, 5501 - 5505

• Tissue repair and the dynamics of the extracellular matrix.

  Midwood KS. et al, (2004), Int J Biochem Cell Biol, 36, 1031 - 1037

• Cell attachment and spreading on metal implant materials

  Schwartz J. et al, (2003), Materials Science and Engineering: C, 23, 395 - 400

• Bonding Organics to Ti Alloys:  Facilitating Human Osteoblast Attachment and Spreading on Surgical Implant Materials

  Gawalt ES. et al, (2003), Langmuir, 19, 200 - 204

• Tenascin-C modulates matrix contraction via focal adhesion kinase- and Rho-mediated signaling pathways.

  Midwood KS. and Schwarzbauer JE., (2002), Mol Biol Cell, 13, 3601 - 3613

• Elastic fibers: building bridges between cells and their matrix.

  Midwood KS. and Schwarzbauer JE., (2002), Curr Biol, 12, R279 - R281

• Preparation and analysis of synthetic multicomponent extracellular matrix.

  Midwood KS. et al, (2002), Methods Cell Biol, 69, 145 - 161

• NG2/HMPG modulation of human articular chondrocyte adhesion to type VI collagen is lost in osteoarthritis.

  Midwood KS. and Salter DM., (2001), J Pathol, 195, 631 - 635

• Tenascin-C suppresses Rho activation.

  Wenk MB. et al, (2000), J Cell Biol, 150, 913 - 920

• Distinct fine specificities of anti-citrullinated peptide antibodies are associated with elevated immune responses to Prevotella intermedia in a subgroup of patients with rheumatoid arthritis and periodontitis

  Midwood K., Arthritis and Rheumatology

Key publications

• Tenascin-C is an endogenous activator of Toll-like receptor 4 that is essential for maintaining inflammation in arthritic joint disease.

  Midwood K. et al, (2009), Nat Med, 15, 774 - 780
• Endogenous control of immunity against infection: tenascin-C regulates TLR4-mediated inflammation via microRNA-155.

  Piccinini AM. and Midwood KS., (2012), Cell Rep, 2, 914 - 926
• Startups on the menu.

  Midwood K., (2013), Nat Biotechnol, 31
• Identification of an immunodominant peptide from citrullinated tenascin-C as a major target for autoantibodies in rheumatoid arthritis.

  Schwenzer A. et al, (2016), Ann Rheum Dis, 75, 1876 - 1883
• Distinct microenvironmental cues stimulate divergent TLR4-mediated signaling pathways in macrophages.

  Piccinini AM. et al, (2016), Sci Signal, 9

Recent Publications

• Screening for Novel Endogenous Inflammatory Stimuli Using the Secreted Embryonic Alkaline Phosphatase NF-κB Reporter Assay.

  Zuliani-Alvarez L. et al, (2017), Bio Protoc, 7
• Tenascin-C at a glance.

  Midwood KS. et al, (2016), J Cell Sci, 129, 4321 - 4327
• Identification of an immunodominant peptide from citrullinated tenascin-C as a major target for autoantibodies in rheumatoid arthritis.

  Schwenzer A. et al, (2016), Ann Rheum Dis, 75, 1876 - 1883
• Distinct microenvironmental cues stimulate divergent TLR4-mediated signaling pathways in macrophages.

  Piccinini AM. et al, (2016), Sci Signal, 9
• Tenascin C upregulates interleukin-6 expression in human cardiac myofibroblasts via toll-like receptor 4.

  Maqbool A. et al, (2016), World J Cardiol, 8, 340 - 350