Contact information
My research background is in haematopoiesis, arthritis and macrophage-lineage cell heterogeneity.
My current research focuses on mechanisms of disease, and identifying biomarkers that predict disease and response to treatment. With support from CRUK, I have recently expanded my research to include different forms of sarcoma, including Ewing's sarcoma.
Felix Clanchy
PhD, LLB
Senior Postdoctoral Researcher
- GMO Safety Committee
- Green Impact
Key publications
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Response to Treatment with TNFα Inhibitors in Rheumatoid Arthritis Is Associated with High Levels of GM-CSF and GM-CSF+ T Lymphocytes.
Journal article
Bystrom J. et al, (2017), Clin Rev Allergy Immunol, 53, 265 - 276
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CD74: an emerging opportunity as a therapeutic target in cancer and autoimmune disease.
Journal article
Borghese F. and Clanchy FIL., (2011), Expert Opin Ther Targets, 15, 237 - 251
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The development of macrophages from human CD34+ haematopoietic stem cells in serum-free cultures is optimized by IL-3 and SCF.
Journal article
Clanchy FIL. and Hamilton JA., (2013), Cytokine, 61, 33 - 37
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High-Affinity Fc Receptor Expression Indicates Relative Immaturity in Human Monocytes.
Journal article
Clanchy FIL., (2016), J Interferon Cytokine Res, 36, 279 - 290
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Ibudilast Inhibits Chemokine Expression in Rheumatoid Arthritis Synovial Fibroblasts and Exhibits Immunomodulatory Activity in Experimental Arthritis.
Journal article
Clanchy FIL. and Williams RO., (2019), Arthritis Rheumatol, 71, 703 - 711
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Targeting early changes in the synovial microenvironment: a new class of immunomodulatory therapy?
Journal article
Aungier SR. et al, (2019), Ann Rheum Dis, 78, 186 - 191
Recent publications
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Pharmacological modulation of T cell immunity results in long-term remission of autoimmune arthritis.
Journal article
Huang Y-S. et al, (2021), Proc Natl Acad Sci U S A, 118
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TLR expression profiles are a function of disease status in rheumatoid arthritis and experimental arthritis
Journal article
Clanchy FIL. et al, (2021), Journal of Autoimmunity, 118, 102597 - 102597