Erinke van Grinsven
Postdoctoral Researcher in Innate Immunity and Inflammation
After finishing my PhD at the University Medical Centre Utrecht in the Netherlands, I joined the Kennedy Institute in January 2019 as a postdoctoral researcher. In my PhD projects, I focused on functional and phenotypical heterogeneity of human and murine neutrophils, both in acute inflammation and in homeostasis.
At the Kennedy Institute, I will focus on neutrophil heterogeneity at a transcriptional level, especially in mouse models of arthritis but also in homeostasis. Previous work in the Udalova group has demonstrated that neutrophil infiltration is a major contributor to joint inflammation in mouse arthritis models. We aim to unravel the transcriptional circuitry that controls neutrophil subtypes in the inflamed joint, thereby identifying novel ways to target those neutrophil subtypes detrimental in disease.
Immature Neutrophils Released in Acute Inflammation Exhibit Efficient Migration despite Incomplete Segmentation of the Nucleus
van Grinsven E. et al, (2019), The Journal of Immunology, 202, 207 - 217
A comprehensive three-dimensional assay to assess neutrophil defense against bacteria
van Grinsven E. et al, (2018), Journal of Immunological Methods, 462, 83 - 90
Two-Photon Intravital Microscopy Animal Preparation Protocol to Study Cellular Dynamics in Pathogenesis
VAN GRINSVEN E. et al, (2017), Light Microscopy Methods and Protocols
A Novel Bacterium-Free Method for Generation of Flavivirus Infectious DNA by Circular Polymerase Extension Reaction Allows Accurate Recapitulation of Viral Heterogeneity
Edmonds J. et al, (2013), Journal of Virology, 87, 2367 - 2372
Characterization of the phenotype of human eosinophils and their progenitors in the bone marrow of healthy individuals
Hassani M. et al, Haematologica