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Elizabeth Mann

Postdoc and Powrie cancer team lead

Colorectal cancer (CRC) is one of the leading causes of cancer-related deaths world-wide, for which a variety of genetic and environmental risk factors are known to exist. One molecule that is known to promote CRC in mouse models of disease is the Th17-family cytokine IL-23. In human CRC, levels of IL-23 are similarly elevated but it's function in disease progression remains poorly understood.

My research aims to uncover the mechanistic role(s) of IL-23 and Th17 cells in human CRC tumours. Insights from these studies will hopefully inform the development of novel diagnostic assays and therapeutics for CRC, particularly focusing on subsets of patients that have poor prognosis.

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