Postdoctoral Research Assistant
Citrullination is a post-translational modification of the amino acid arginine that occurs at sites of inflammation, and which is particularly elevated in chronic inflammatory diseases such as rheumatoid arthritis.
The aim of my work is to understand the impact of this modification on the extracellular matrix, especially how it affects the pro-inflammatory action of the matrix molecule tenascin-C.
I am also investigating whether citrullinated tenascin-C is targeted by the autoantibody response in rheumatoid arthritis. Together this information can help to improve both the diagnosis and treatment of arthritis.
Green: unmodified arginines
Schwenzer A. et al, (2016), Ann Rheum Dis, 75, 1876 - 1883
Raza K. et al, (2016), RMD Open, 2
The extracellular matrix and cancer: regulation of tumor cell biology by tenascin-C
Orend G. et al, (2014)
Saupe F. et al, (2013), Cell Rep, 5, 482 - 492