Contact information
Research groups
Anja Schwenzer
Postdoctoral Research Assistant
Citrullination is a post-translational modification of the amino acid arginine that occurs at sites of inflammation, and which is particularly elevated in chronic inflammatory diseases such as rheumatoid arthritis.
The aim of my work is to understand the impact of this modification on the extracellular matrix, especially how it affects the pro-inflammatory action of the matrix molecule tenascin-C.
I am also investigating whether citrullinated tenascin-C is targeted by the autoantibody response in rheumatoid arthritis. Together this information can help to improve both the diagnosis and treatment of arthritis.
Blue: citrulline
Green: unmodified arginines
Recent publications
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Journal article
Gschwandtner M. et al, (2023), Int J Mol Sci, 24
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FAS2FURIOUS: Moderate-throughput secreted expression of difficult recombinant proteins in Drosophila S2 cells
Journal article
MIDWOOD KIM. et al, (2022), Frontiers in Bioengineering and Biotechnology, section Synthetic Biology
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Journal article
Song J. et al, (2021), JCI Insight
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T and B Cell Responses to Common Tenascin-C Peptides in RA
Conference paper
Song J. et al, (2020), ARTHRITIS & RHEUMATOLOGY, 72
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Journal article
Giblin SP. et al, (2020), Matrix Biol