Work in the Sansom lab focuses on identifying the cellular and molecular causes of immune-mediated inflammatory disease (IMID) using systems-level approaches.
Loss of tissue homeostasis in diseases such as spondyloarthritis (SpA) and inflammatory bowel disease (IBD) involves dysregulated signalling between heterogenous populations of immune and stromal cells. We are using single cell and functional genomics-based approaches to decipher this complexity and advance understanding of the cellular circuits, biological pathways and genes that cause and sustain disease. A second area of the groups interests lies in the field of immune system development. The use of data science approaches to model, contextualise and interpret complex datasets is central to our research.
Currently we are pursuing projects in the following areas:
1. Investigating the cellular causes of HLA-B27 associated spondyloarthritis
2. Investigating fibroblast heterogeneity in rheumatoid arthritis
3. Mapping the cell types present in healthy human joints
4. Investigating the role of mononuclear phagocytes in inflammatory bowel disease
5. The role of thymic epithelial cells in central tolerance