Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

There is a bewildering array of dressing materials available for wound coverage. The choice of dressing is often by local custom or practical experience. We wished to investigate if different dressings varied in their ability to either stimulate or inhibit proliferative activity and differentiation in an in vitro test system. We have used a number of test systems for this study. Human dermal fibroblast and keratinocyte cultures were used to screen for proliferative and cytotoxic effects. A more complex "organotypic" method involving fibroblast-impregnated collagen gels overlaid with epidermal keratinocytes was used to investigate effects on differentiation. Dressings were selected from each of the major types available, from simple gauze to hydrocolloids. Of the dressings tested, some reduced cell growth rates but the majority showed no major effect on proliferation or differentiation. Of those displaying an effect, only one could be attributed to cytotoxicity.

Original publication




Journal article


Br J Plast Surg

Publication Date





230 - 235


3T3 Cells, Animals, Bandages, Cell Differentiation, Cells, Cultured, DNA, Fibroblasts, Humans, Keratinocytes, Mice, Proteins, Toxicity Tests