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BACKGROUND: The factors determining differential HIV disease outcome among individuals expressing protective HLA alleles such as HLA-B*27:05 and HLA-B*57:01 remain unknown. We here analyse two HIV-infected subjects expressing both HLA-B*27:05 and HLA-B*57:01. One subject maintained low-to-undetectable viral loads for more than a decade of follow up. The other progressed to AIDS in 

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CTL response, HIV-1, HLA, Superinfection, Transmission pair, Ultra-deep sequencing, Amino Acid Substitution, CD4 Lymphocyte Count, CD4-Positive T-Lymphocytes, Cluster Analysis, Disease Progression, Epitopes, T-Lymphocyte, Genetic Variation, HIV Core Protein p24, HIV Infections, HIV-1, HLA-B Antigens, High-Throughput Nucleotide Sequencing, Humans, Male, RNA, Viral, Sequence Analysis, RNA, Superinfection, T-Lymphocytes, Cytotoxic, Viral Load, Virus Replication, gag Gene Products, Human Immunodeficiency Virus