Rapid HIV disease progression following superinfection in an HLA-B*27:05/B*57:01-positive transmission recipient.
Brener J., Gall A., Hurst J., Batorsky R., Lavandier N., Chen F., Edwards A., Bolton C., Dsouza R., Allen T., Pybus OG., Kellam P., Matthews PC., Goulder PJR.
BACKGROUND: The factors determining differential HIV disease outcome among individuals expressing protective HLA alleles such as HLA-B*27:05 and HLA-B*57:01 remain unknown. We here analyse two HIV-infected subjects expressing both HLA-B*27:05 and HLA-B*57:01. One subject maintained low-to-undetectable viral loads for more than a decade of follow up. The other progressed to AIDS in