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Studies of stromal cell populations in lymphoid tissue (LT) have been hampered by a lack of selective markers. Here, we show that CD248 (Endosialin/TEM1) is a stromal marker that is differentially expressed on fibroblasts and pericytes in the thymus, lymph node and spleen. Expression is high during LT development but largely disappears in the adult. CD248 is re-expressed in a Salmonella-induced model of splenic enlargement; peak expression corresponding to the peak of splenic enlargement. These results suggest that CD248 expression helps define a subset of LT stromal cells which play a role in remodelling during tissue development, infection and repair.

Original publication

DOI

10.1016/j.febslet.2007.06.063

Type

Journal article

Journal

FEBS Lett

Publication Date

24/07/2007

Volume

581

Pages

3550 - 3556

Keywords

Animals, Antigens, CD, B-Lymphocytes, Biomarkers, Cell Count, Gene Expression Regulation, Developmental, Lymphoid Tissue, Mice, Mice, Inbred C57BL, Neoplasm Proteins, Platelet Endothelial Cell Adhesion Molecule-1, Salmonella Infections, Spleen, Stromal Cells, Time Factors