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CBA/Ca mice were infected by either the intravenous or intraperitoneal route with Mycobacterium microti and the subsequent changes in local macrophage populations examined. Following infection, the number of macrophages increased and they showed greater expression of both MHC Class II molecules. This response was not dependent on viability of the mycobacteria, in contrast to reports with other microorganisms such as Listeria. Studies in sublethally irradiated mice indicated that persistent antigen could give rise to a response after a period of host recovery which was radiation dose dependent. This procedure also highlighted differences in the regulation of different murine class II antigens in vivo, as seen by delayed re-expression of I-E antigens. Macrophage accessory cell function, as assessed by an in vitro T cell proliferation assay, correlated with Ia expression after fixation, but not after indomethacin treatment; this highlights the diverse nature of regulatory molecules produced by these cells.

Type

Journal article

Journal

Clin Exp Immunol

Publication Date

04/1986

Volume

64

Pages

20 - 27

Keywords

Animals, Antigen-Presenting Cells, Dose-Response Relationship, Radiation, Female, Histocompatibility Antigens Class II, Indomethacin, Macrophages, Mice, Mice, Inbred CBA, Mitosis, Mycobacterium Infections, T-Lymphocytes, Whole-Body Irradiation