Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Rheumatoid arthritis and periodontitis are two prevalent chronic inflammatory diseases in humans and are associated with each other both clinically and epidemiologically. Recent findings suggest a causative link between periodontal infection and rheumatoid arthritis via bacteria-dependent induction of a pathogenic autoimmune response to citrullinated epitopes. Here we showed that infection with viable periodontal pathogen Porphyromonas gingivalis strain W83 exacerbated collagen-induced arthritis (CIA) in a mouse model, as manifested by earlier onset, accelerated progression and enhanced severity of the disease, including significantly increased bone and cartilage destruction. The ability of P. gingivalis to augment CIA was dependent on the expression of a unique P. gingivalis peptidylarginine deiminase (PPAD), which converts arginine residues in proteins to citrulline. Infection with wild type P. gingivalis was responsible for significantly increased levels of autoantibodies to collagen type II and citrullinated epitopes as a PPAD-null mutant did not elicit similar host response. High level of citrullinated proteins was also detected at the site of infection with wild-type P. gingivalis. Together, these results suggest bacterial PAD as the mechanistic link between P. gingivalis periodontal infection and rheumatoid arthritis.

Original publication

DOI

10.1371/journal.ppat.1003627

Type

Journal article

Journal

PLoS Pathog

Publication Date

09/2013

Volume

9

Keywords

Animals, Arthritis, Autoantibodies, Bacterial Proteins, Bacteroidaceae Infections, Bone Resorption, Citrulline, Disease Models, Animal, Disease Progression, Gene Deletion, Hydrolases, Joints, Male, Mice, Inbred DBA, Neutrophil Infiltration, Periodontitis, Porphyromonas gingivalis, Prevotella intermedia, Protein Processing, Post-Translational, Severity of Illness Index