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Analysing cell migration and invasion is of interest to many investigators as they mimic a part of physiological or pathological events. In this chapter, methods to analyse MMP-dependent 2D and 3D cell migration are described in detail. To study 2D cell migration, the phagokinetic track motility assay can be used. To study 3D cell migration, Matrigel invasion assay or microcarrier beads invasion assay can be used to obtain quantitative results.

Original publication




Journal article


Methods Mol Biol

Publication Date





379 - 392


Animals, Biological Assay, Cell Line, Cell Movement, Collagen, Drug Combinations, Laminin, Matrix Metalloproteinases, Microspheres, Proteoglycans