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Recent studies suggest that psoriasis may be more severe in patients with nonalcoholic fatty liver disease, particularly in those with the inflammatory stage of steatohepatitis [nonalcoholic steatohepatitis (NASH)]. Herein, we investigated the impact of diet-induced steatohepatitis on the severity of imiquimod-induced psoriasiform dermatitis. Mice fed with a high-fat diet developed steatohepatitis reminiscent of human NASH with ballooning hepatocytes and significant liver fibrosis. Mice with steatohepatitis also displayed moderate cutaneous inflammation characterized by erythema, dermal infiltrates of CD45(+) leukocytes, and a local production of IL-17A. Moreover, steatohepatitis was associated with an epidermal activation of caspase-1 and cutaneous overexpression of IL-1β. Imiquimod-induced psoriasiform dermatitis was exacerbated in mice with steatohepatitis as compared to animals fed with a standard diet. Scale formation and acanthosis were aggravated, in correlation with increased IL-17A and IL-22 expression in inflamed skins. Finally, intradermal injection of IL-17A in standard diet-fed mice recapitulated the cutaneous pathology of mice with steatohepatitis. The results show that high-fat diet-induced steatohepatitis aggravates the inflammation in psoriasiform dermatitis, via the cutaneous production of IL-17A. In agreement with clinical data, this description of a novel extrahepatic manifestation of NASH should sensitize dermatologists to the screening and the management of fatty liver in psoriatic patients.

Original publication




Journal article


The American journal of pathology

Publication Date





2292 - 2301


Department of Hepatogastroenterology, Poitiers University Hospital, Poitiers, France; Laboratory of Inflammation and Epithelial and Cytokine Tissues EA 4331, CNRS ERL 7368, Poitiers University, Poitiers, France. Electronic address:


Animals, Mice, Inbred C57BL, Mice, Dermatitis, Disease Models, Animal, Interleukin-17, Fluorescent Antibody Technique, Flow Cytometry, Male, Real-Time Polymerase Chain Reaction, Diet, High-Fat, Non-alcoholic Fatty Liver Disease