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Mammals coexist in an overall symbiotic relationship with a complex array of commensal bacterial flora that colonizes the gastrointestinal tract. These intestinal bacteria interface with cells of the mucosal immune system, including DCs. Here we discuss mechanisms of interaction between intestinal bacteria and DCs and the role of localized gastrointestinal immune responses.

Original publication

DOI

10.1172/JCI19545

Type

Journal article

Journal

J Clin Invest

Publication Date

09/2003

Volume

112

Pages

648 - 651

Keywords

Animals, Dendritic Cells, Humans, Immunity, Mucosal, Inflammatory Bowel Diseases, Interleukin-23, Interleukin-23 Subunit p19, Interleukins, Intestines, Mice