Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Professor Simon has been successful in her Wellcome Trust Investigator Award entitled: “Proteostasis and Autophagy in Immune Senescence.”

Katja Simon, Professor of Immunology at the Kennedy Institute of Rheumatology has been awarded £1.8M over 5 years to explore the mechanics of autophagy and the role it plays in preventing ageing.

Healthcare challenges are intensifying as our population ages as age is the biggest single risk factor for many debilitating diseases, from infections to cancer. Immune ageing contributes by preventing useful immune responses as well as to other age-related diseases such as neurodegeneration, cardiovascular disease and cancer. But this process is little studied. Autophagy, a pathway activated when cells are stressed, clears away debris accumulated over time, recycling building blocks for re-use.

“Declining autophagy underpins ageing in many tissues, especially, as we have shown, in the immune system. We now want to identify what is degraded and what is generated by autophagy, to better understand how it prevents aging,” said Professor Simon. “I am delighted to receive this award as it will give my team and me the opportunity to study the underlying causes of aging both at a basic science level as well as trying to identify new drugs.

The award will enable Professor Simon to study how autophagy controls the amino acid pool and cellular energy levels and thereby protein synthesis. While protein synthesis levels decline with age, previous studies found that increasing the synthesis of autophagy proteins alone rejuvenates immune cells. By studying this pathway, they hope to identify new ways to prevent or even reverse the aging of immune cells.

Similar stories

Versus Arthritis Foundation Fellowship awarded to Dr Kristina Zec

Awards

Dr Kristina Zec has been awarded a Versus Arthritis Foundation Fellowship to investigate the role of products of lipid oxidation produced by synovial macrophages in triggering articular inflammation.

Oxford University awarded £2.4 million to fund DPhil research in inflammation, immunology and musculoskeletal disease

Awards Funding

Oxford University has today been awarded a £2.4 million grant, as part of the Kennedy Trust MB PhD scheme, to fund undergraduate medical students to undertake DPhil research in the areas of inflammation, immunology and musculoskeletal disease.

£3M invested to drive forward early translation through five new Oxford-Bristol Myers Squibb Fellowships

Awards General

Five new Oxford-Bristol Myers Squibb Fellowships representing an investment of £3M have been announced. The fellowships (formerly Oxford-Celgene) will support postdoctoral researchers and clinicians across five departments within the Medical Sciences Division and the Mathematical, Physical and Life Sciences Division, providing an opportunity for them to gain exposure to the field of commercial drug discovery and development.

Wellcome funding awarded to Oxford team to support research into heart muscle regeneration

Awards Research

An Oxford team from the Centre for Medicines Development, Department of Physiology Anatomy and Genetics and Radcliffe Department of Medicine led by Professor Jagdeep Nanchahal at the Kennedy Institute has been awarded a Wellcome Innovator Award to develop a first in class therapeutic aimed at regenerating heart muscle after heart attack.

NDORMS researchers make Highly Cited Researchers list

Awards

Professor Gary Collins, Professor Cyrus Cooper, Professor Fiona Powrie and the late Professor Doug Altman have been named on the annual Highly Cited Researchers™️ 2020 list from Clarivate.

NDORMS staff recognised for excellence in teaching and research

Awards

Three NDORMS researchers have been awarded new titles in the University of Oxford's 2020 Recognition of Distinction exercise.