- Simon Group | Autophagy in the Immune System Research Group
Recent Webinar in Nature on how autophagy prevents immune senescence.
In the media
Article in The Guardian covering Professor Simon's research in autophagy and links to disease and ageing.
Anna Katharina (Katja) A Simon
Professor of Immunology
Katja Simon is studying cell fate in the hematopoietic system. She trained as an Immunologist under Avrion Mitchison at the DRFZ Berlin and found that TH1 cytokines are found in excess in human autoimmune diseases in her PhD. As a postdoc at the Centre d'Immunologie Marseille Luminy, she investigated transcription factors regulating thymic cell death. During her second postdoc in Oxford she pursued her interest in cell fate, studying cell death molecules (Trail and FasL) in thymic selection, inflammation and tumour immunity. As a principal investigator, she set up an independent line of enquiry investigating autophagy, another cellular process determining cell fate, in the hemato-immune system. Her group discovered that autophagy, the main conserved cellular bulk degradation pathway, maintains healthy red blood cells, stem cells and memory T cells and promotes differentiation while preventing ageing of the hematopoietic system.
Riffelmacher T. and Simon AK., (2017), FEBS J, 284, 1008 - 1020
Liao C. et al, (2017), Neurology, 88, 131 - 142
Simon AK. and Clarke AJ., (2016), Cell Death Differ, 23, 1267 - 1268
Zhang H. et al, (2016), Trends Mol Med, 22, 671 - 686
Kabat AM. et al, (2016), Elife, 5