Nicole Horwood
Honorary Departmental Research Associate.
Associate Professor Horwood is the Principal Investigator of the Osteoimmunology Research group at The Kennedy Institute of Rheumatology, NDORMS, University of Oxford.
She completed her PhD on osteoclast differentiation in 1999 at St Vincent’s Institute, University of Melbourne. She was subsequently awarded the Victoria Premiers Commendation for Medical Research in 2000 as well as a Howard Florey fellowship from the Royal Society for postdoctoral studies at the Kennedy Institute, Imperial College London with Professor Sir Marc Feldmann and Professor Brian Foxwell.
She was appointed to a lectureship in 2004 and is now an associate professor with The University of Oxford.
She is currently a Senior Research Fellow of Arthritis Research UK. Current research projects investigate links between bone cell function and multiple myeloma, inflammation and fracture repair, factors controlling osteoblast dedifferentiation, and mechanisms of new bone formation in ankylosing spondylitis and osteoarthritis.
Key publications
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Dual-specificity phosphatase 1-null mice exhibit spontaneous osteolytic disease and enhanced inflammatory osteolysis in experimental arthritis.
Vattakuzhi Y. et al, (2012), Arthritis Rheum, 64, 2201 - 2210
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Monocytes induce STAT3 activation in human mesenchymal stem cells to promote osteoblast formation.
Nicolaidou V. et al, (2012), PLoS One, 7
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Glycosphingolipid synthesis inhibition limits osteoclast activation and myeloma bone disease.
Ersek A. et al, (2015), J Clin Invest, 125, 2279 - 2292
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Selective inhibition of TNFR1 reduces osteoclast numbers and is differentiated from anti-TNF in a LPS-driven model of inflammatory bone loss.
Espirito Santo AI. et al, (2015), Biochem Biophys Res Commun, 464, 1145 - 1150
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Inhibition of osteoclast function reduces hematopoietic stem cell numbers in vivo.
Lymperi S. et al, (2011), Blood, 117, 1540 - 1549
Recent publications
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Fully reduced HMGB1 accelerates the regeneration of multiple tissues by transitioning stem cells to GAlert.
Lee G. et al, (2018), Proc Natl Acad Sci U S A, 115, E4463 - E4472
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Bruton's tyrosine kinase regulates TLR7/8-induced TNF transcription via nuclear factor-κB recruitment.
Page TH. et al, (2018), Biochem Biophys Res Commun, 499, 260 - 266
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HMGB1 accelerates regeneration of multiple tissues by transitioning stem cells to G(Alert)
Lee G. et al, (2018), AUSTRALASIAN JOURNAL OF DERMATOLOGY, 59, 83 - 83
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HMGB1 accelerates regeneration of multiple tissues by transitioning stem cells to G(Alert)
Lee G. et al, (2017), JOURNAL OF BONE AND MINERAL RESEARCH, 32, S48 - S48
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NOVEL MODELS OF LATE ONSET, PROGRESSIVE OSTEOARTHRITIS CAUSED BY POINT MUTATIONS IN THE TWO ALPHA CHAINS OF COLLAGEN TYPE I
Blease AM. et al, (2017), OSTEOARTHRITIS AND CARTILAGE, 25, S56 - S56