Senior Lecturer and Versus Arthritis Senior Fellow
Dr Lucy Norling is a Senior Lecturer at the William Harvey Research Institute, Queen Mary University of London. She graduated with a Masters in Research and PhD from the WHRI in 2008 and was awarded a 3-year Arthritis Research UK Foundation Fellowship to study the generation and bioactions of novel lipid mediators derived from omega-3 fatty acids. During this time, she spent two years training at Harvard Medical School, Boston, with the mentorship of Professor Charles Serhan.
In 2012, Dr Norling attained a 5-year Arthritis Research UK Career Development Fellowship to investigate the protective actions of omega-3 fatty acid derived specialized pro-resolving lipid mediators (SPM) in inflammatory arthritis. SPM provide a molecular mechanism for the beneficial effects of fish oil supplementation in patients with arthritis and offer novel therapeutic approaches to treat inflammatory diseases.
There is a clear need to develop new innovative therapeutic agents for arthritis that can both reduce the inflammation that drives disease AND initiate tissue repair and regeneration. With the support of a Versus Arthritis Senior Fellowship awarded in 2019, her group aims to establish how SPM reprogram innate immune cells and stromal cells within the joint tissue to switch on repair mechanisms that temper the aggressive and inappropriate behaviour of cells within the joint tissue to ultimately protect the cartilage from erosion. Her group consists of four PhD students and a post-doctoral fellow addressing important research questions regarding the role of proteins, lipids and microvesicles on inflammation-resolution.