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Kate Coldwell
PhD, PGCE
Daphne Jackson Trust Fellow
Disentangling the temporal interplay between the liver and gut in primary sclerosing cholangitis
Primary sclerosing cholangitis (PSC) is a rare liver disease with no effective treatment. Its aetiology is complex but likely involves links between the gut, gut microbiome and liver. To understand the disease better, we are studying markers of intestinal inflammation, intestinal permeability and microbiome-derived metabolites in the longitudinal DYNAMHIX in PSC study, asking 'how does disrupted bile flow in PSC affect the gut microbiome, and conversely, how does the disruption to the gut microbiome affect the liver?'