Colleges
Jagdeep Nanchahal
Professor of Hand, Plastic and Reconstructive Surgery
Jagdeep undertook his PhD, funded by the MRC, whilst a medical student in London and trained as a reconstructive plastic surgeon. His research is focussed on identifying novel therapeutic targets for reducing fibrosis and promoting tissue regeneration, and translating his findings through to clinical trials.
In 2013 his group identified TNF as therapeutic target for Dupuytren’s disease, a common fibrotic condition of the hand. He was chief investigator for a phase 2a followed by a recently completed phase 2b clinical by the Wellcome Trust and Department of Health and 180 Life Sciences to assess the efficacy of local administration of anti-TNF in patients with early stage Dupuytren’s disease. The trials showed that intranodular injections of adalimumab downregulate myofibroblast phenotype and lead to softening and decrease in size of the nodules of early-stage disease, which continue for up to 9 months after the final injection. He is co-chief investigator for a trial of anti-TNF for early stage, pain-predominant frozen shoulder and co-applicant on a trial led by Prof Matt Costa at the Kadoorie Centre of anti-TNF for preventing delirium in patients undergoing surgery for hip fractures.
His group has also identified a novel mechanism for promoting repair and regeneration of multiple tissues by targeting endogenous stem cells and is developing HMGB1 as a therapeutic with funding from a Wellcome Trust Innovator Award.
He is a proponent of evidence-based medicine and was the only plastic surgery member of the NICE Guidance Development Groups on complex and non-complex fractures.
Key publications
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Journal article
Nanchahal J. et al, (2022), The Lancet Rheumatology
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Lee G. et al, (2018), Proc Natl Acad Sci U S A, 115, E4463 - E4472
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Nanchahal J. and Hinz B., (2016), Proceedings of the National Academy of Sciences of USA, 113, 7291 - 7293
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Journal article
Nanchahal J. et al, (2018), EBioMedicine, 33, 282 - 288
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Chan JK. et al, (2012), J Clin Invest, 122, 2711 - 2719
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Jain A. et al, (2002), Lancet, 360, 1565 - 1566
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Verjee LS. et al, (2013), Proc Natl Acad Sci U S A, 110, E928 - E937
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Izadi D. et al, (2019), Sci Adv, 5
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Williams LM. et al, (2020), Proc Natl Acad Sci U S A, 117, 20753 - 20763
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Layton TB. et al, (2020), Nat Commun, 11
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Costa ML. et al, (2020), JAMA, 323, 519 - 526
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Chan JK-K. et al, (2022), Cochrane Database Syst Rev, 4
Recent publications
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Brady S. et al, (2024), BMJ Open, 14
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Riesmeijer SA. et al, (2024), Nat Commun, 15
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Hopewell S. et al, (2023), NIHR Open Research, 2, 28 - 28
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Nanchahal J. and Chan JK-K., (2023), Journal of Hand Surgery (European Volume), 175319342211313 - 175319342211313
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Layton TB. et al, (2022), Trends Mol Med
SYSTEMATIC REVIEWS
Berner JE, Pereira N, Troisi L, Will P, Nanchahal J, Jain A (2020) Journal of Plastic, Reconstructive & Aesthetic Surgery. |
Systematic review of non-surgical treatments for early Dupuytren’s disease. Ball C, Izadi D, Verjee LS, Chan J K-K, Nanchahal J (2016) BMC Musculoskeletal Disorders. 17(1): 345 Referenced in NICE Interventional procedure review of radiation therapy for early Dupuytren’s disease 201:6 IP780/2 (IPG573) |
Standards for the Management of Open Tibial Fractures. Contribution to chapters on Prehospital and Emergency Care and Antibiotic Prophylaxis, Timing of Wound Excision, Wound Excision, Degloving Injuries, Temporary Dressings, Soft Tissue Reconstruction, Vascular Injuries, Open Fragility Fractures Eccles S, Handley R, Khan U, McFadyen I, Nanchahal J, Nayagan, S (listed alphabetically) (2020) Oxford University Press. ISBN-13: 9780198849360 |