Jacqueline Siu
Wellcome Trust Early Career Fellow in Immunology
Jacqueline is a Wellcome Trust Early Career Fellow in the Coles/ Dendrou Lab at the Kennedy Institute of Rheumatology.
Jacqueline’s research focus is to understand the role of early human B cell response (extrafollicular response) which has a vital role in rapid antibody production. By integrating human challenge models, ex vivo cultures, and single-cell genomics, she aims to address a fundamental immunological question about early human B cells and their impact on long-lived antibodies. Findings may facilitate tailored next generation vaccination and adjuvant strategies to enhance long-term memory responses.
Recent publications
Early lymph node T follicular helper cell signalling hub drives influenza vaccine response in an ancestrally diverse cohort.
Journal article
Siu JHY. et al, (2025), EBioMedicine, 122
Insights, opportunities, and challenges provided by large cell atlases.
Journal article
Hemberg M. et al, (2025), Genome Biol, 26
Ex vivo model of functioning human lymph node reveals role for innate lymphocytes and stroma in response to vaccine adjuvant.
Journal article
Fergusson JR. et al, (2025), Cell Rep, 44
Early regional lymph node activation drives influenza vaccine responses in an ancestrally diverse cohort
Preprint
Siu JHY. et al, (2024)
longitudinal single-cell atlas of anti-tumour necrosis factor treatment in inflammatory bowel disease.
Journal article
Thomas T. et al, (2024), Nat Immunol, 25, 2152 - 2165