Christopher Buckley

• Priming in response to pro-inflammatory cytokines is a feature of adult synovial but not dermal fibroblasts

  Journal article

  Crowley T. et al, (2017), Arthritis Research & Therapy, 19

• Detection and characterisation of bone destruction in murine rheumatoid arthritis using statistical shape models

  Journal article

  Brown JM. et al, (2017), Medical Image Analysis, 40, 30 - 43

• Genomic Responses of Mouse Synovial Fibroblasts During Tumor Necrosis Factor-Driven Arthritogenesis Greatly Mimic Those in Human Rheumatoid Arthritis.

  Journal article

  Ntougkos E. et al, (2017), Arthritis Rheumatol, 69, 1588 - 1600

• Multimerin-2 is a ligand for group 14 family C-type lectins CLEC14A, CD93 and CD248 spanning the endothelial pericyte interface

  Journal article

  Khan KA. et al, (2017), Oncogene

• The role of stromal cells in inflammatory bone loss

  Journal article

  Wehmeyer C. et al, (2017), Clinical & Experimental Immunology, 189, 1 - 11

• Gain-of-Function Mutation of Tristetraprolin Impairs Negative Feedback Control of Macrophages In Vitro yet Has Overwhelmingly Anti-Inflammatory Consequences In Vivo.

  Journal article

  O'Neil JD. et al, (2017), Mol Cell Biol, 37

• Plasma Levels of Eicosapentaenoic Acid Are Associated with Anti-TNF Responsiveness in Rheumatoid Arthritis and Inhibit the Etanercept-driven Rise in Th17 Cell Differentiation in Vitro.

  Journal article

  Jeffery L. et al, (2017), J Rheumatol, 44, 748 - 756

• Pre-symptomatic autoimmunity in rheumatoid arthritis: when does the disease start?

  Journal article

  Tracy A. et al, (2017), Seminars in Immunopathology, 39, 423 - 435

• EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2016 update

  Journal article

  Smolen JS. et al, (2017), Annals of the Rheumatic Diseases, 76, 960 - 977

• Epigenetically-driven anatomical diversity of synovial fibroblasts guides joint-specific fibroblast functions

  Journal article

  Frank-Bertoncelj M. et al, (2017), Nature Communications, 8, 14852 - 14852

• Treatment of inflammatory arthritis via targeting of tristetraprolin, a master regulator of pro-inflammatory gene expression.

  Journal article

  Ross EA. et al, (2017), Ann Rheum Dis, 76, 612 - 619

• Persistent stromal fibroblast activation is present in chronic tendinopathy.

  Journal article

  Dakin SG. et al, (2017), Arthritis Res Ther, 19

• Postnatal Deletion of Podoplanin in Lymphatic Endothelium Results in Blood Filling of the Lymphatic System and Impairs Dendritic Cell Migration to Lymph NodesHighlights

  Journal article

  Bianchi R. et al, (2017), Arteriosclerosis, Thrombosis, and Vascular Biology, 37, 108 - 117

• Patients' Perceptions of Their Relatives' Risk of Developing Rheumatoid Arthritis and of the Potential for Risk Communication, Prediction, and Modulation

  Journal article

  Falahee M. et al, (2016), Arthritis Care & Research

• 11β-Hydroxysteroid dehydrogenase type 1 within muscle protects against the adverse effects of local inflammation

  Journal article

  Hardy RS. et al, (2016), The Journal of Pathology, 240, 472 - 483

• Rheumatoid synovial fibroblasts differentiate into distinct subsets in the presence of cytokines and cartilage

  Journal article

  Croft AP. et al, (2016), Arthritis Research & Therapy, 18

• Role of CD248 as a potential severity marker in idiopathic pulmonary fibrosis

  Journal article

  Bartis D. et al, (2016), BMC Pulmonary Medicine, 16

• DKK1 expression by synovial fibroblasts in very early rheumatoid arthritis associates with lymphocyte adhesion in an in vitro flow co-culture system

  Journal article

  Juarez M. et al, (2016), Arthritis Research & Therapy, 18

• Stromal Fibroblasts in Tertiary Lymphoid Structures: A Novel Target in Chronic Inflammation

  Journal article

  Barone F. et al, (2016), Frontiers in Immunology, 7

• Decrease in articular hypoxia and synovial blood flow at early time points following infliximab and etanercept treatment in rheumatoid arthritis.

  Journal article

  Fisher BA. et al, (2016), Clin Exp Rheumatol, 34, 1072 - 1076

• Tumour necrosis factor inhibition versus rituximab for patients with rheumatoid arthritis who require biological treatment (ORBIT): an open-label, randomised controlled, non-inferiority, trial.

  Journal article

  Porter D. et al, (2016), Lancet, 388, 239 - 247

• CD248/endosialin critically regulates hepatic stellate cell proliferation during chronic liver injury via a PDGF-regulated mechanism

  Journal article

  Wilhelm A. et al, (2016), Gut, 65, 1175 - 1185

• Perceptions of risk and predictive testing held by the first-degree relatives of patients with rheumatoid arthritis in England, Austria and Germany: a qualitative study

  Journal article

  Stack RJ. et al, (2016), BMJ Open, 6, e010555 - e010555

• Identification of novel antiacetylated vimentin antibodies in patients with early inflammatory arthritis

  Journal article

  Juarez M. et al, (2016), Annals of the Rheumatic Diseases, 75, 1099 - 1107

• Synovial CD4+ T-cell-derived GM-CSF supports the differentiation of an inflammatory dendritic cell population in rheumatoid arthritis

  Journal article

  Reynolds G. et al, (2016), Annals of the Rheumatic Diseases, 75, 899 - 907

• Epidermal Notch1 recruits RORγ+ group 3 innate lymphoid cells to orchestrate normal skin repair

  Journal article

  Li Z. et al, (2016), Nature Communications, 7, 11394 - 11394

• Expression of chemokines CXCL4 and CXCL7 by synovial macrophages defines an early stage of rheumatoid arthritis.

  Journal article

  Yeo L. et al, (2016), Ann Rheum Dis, 75, 763 - 771

• Increased expression of inducible co-stimulator on CD4+ T-cells in the peripheral blood and synovial fluid of patients with failed hip arthroplasties.

  Journal article

  Revell PA. et al, (2016), Bone Joint Res, 5, 52 - 60

• Periodontitis prevalence and serum antibody reactivity to periodontal bacteria in primary Sjögren's syndrome: a pilot study

  Journal article

  Lugonja B. et al, (2016), Journal of Clinical Periodontology, 43, 26 - 33

• Patient and researcher perspectives on facilitating patient and public involvement in rheumatology research

  Journal article

  Pollock J. et al, (2016), Musculoskeletal Care

• Detection of antibodies to citrullinated tenascin-C in patients with early synovitis is associated with the development of rheumatoid arthritis.

  Journal article

  Raza K. et al, (2016), RMD Open, 2

• Cytokines in rheumatoid arthritis — shaping the immunological landscape

  Journal article

  McInnes IB. et al, (2015), Nature Reviews Rheumatology, 12, 63 - 68

• Release of Active Peptidyl Arginine Deiminases by Neutrophils Can Explain Production of Extracellular Citrullinated Autoantigens in Rheumatoid Arthritis Synovial Fluid

  Journal article

  Spengler J. et al, (2015), Arthritis & Rheumatology, 67, 3135 - 3145

• Celebrating the past, concentrating on the future: the next decade for AR&T

  Journal article

  Buckley CD. and Perlman H., (2015), Arthritis Research & Therapy, 17

• Inflammation drives thrombosis after Salmonella infection via CLEC-2 on platelets

  Journal article

  Hitchcock JR. et al, (2015), Journal of Clinical Investigation, 125, 4429 - 4446

• CD31 signals confer immune privilege to the vascular endothelium

  Journal article

  Cheung K. et al, (2015), Proceedings of the National Academy of Sciences, 112, E5815 - E5824

• IL-22 regulates lymphoid chemokine production and assembly of tertiary lymphoid organs

  Journal article

  Barone F. et al, (2015), Proceedings of the National Academy of Sciences, 112, 11024 - 11029

• The expression of mouse CLEC-2 on leucocyte subsets varies according to their anatomical location and inflammatory state.

  Journal article

  Lowe KL. et al, (2015), European journal of immunology, 45, 2484 - 2493

• The autoimmune-associated genetic variant PTPN22 R620W enhances neutrophil activation and function in patients with rheumatoid arthritis and healthy individuals

  Journal article

  Bayley R. et al, (2015), Annals of the Rheumatic Diseases, 74, 1588 - 1595

• Dual-Specificity Phosphatase 1 and Tristetraprolin Cooperate To Regulate Macrophage Responses to Lipopolysaccharide.

  Journal article

  Smallie T. et al, (2015), J Immunol, 195, 277 - 288

• Dominant Suppression of Inflammation via Targeted Mutation of the mRNA Destabilizing Protein Tristetraprolin.

  Journal article

  Ross EA. et al, (2015), J Immunol, 195, 265 - 276

• Podoplanin and CLEC-2 drive cerebrovascular patterning and integrity during development

  Journal article

  Lowe KL. et al, (2015), Blood, 125, 3769 - 3777

• Spondyloarthropathy: interleukin 23 and disease modification.

  Journal article

  Sherlock JP. et al, (2015), Lancet, 385, 2017 - 2018

• Differential glucocorticoid metabolism in patients with persistent versus resolving inflammatory arthritis.

  Journal article

  Nanus DE. et al, (2015), Arthritis Res Ther, 17

• New pathogenic insights into rheumatoid arthritis

  Journal article

  Jutley G. et al, (2015), Current Opinion in Rheumatology, 27, 249 - 255

• Pathways involved in the resolution of inflammatory joint disease

  Journal article

  Haworth O. and Buckley CD., (2015), Seminars in Immunology, 27, 194 - 199

• Expression of FcRL4 defines a pro-inflammatory, RANKL-producing B cell subset in rheumatoid arthritis

  Journal article

  Yeo L. et al, (2015), Annals of the Rheumatic Diseases, 74, 928 - 935

• Homeostatic regulation of T cell trafficking by a B cell–derived peptide is impaired in autoimmune and chronic inflammatory disease

  Journal article

  Chimen M. et al, (2015), Nature Medicine, 21, 467 - 475

• 154. Perceptions of Testing to Predict Future Development of Rheumatoid Arthritis among the First-Degree Relatives of People with Rheumatoid Arthritis: A Qualitative Exploration

  Journal article

  (2015), Rheumatology

• Stromal Transcriptional Profiles Reveal Hierarchies of Anatomical Site, Serum Response and Disease and Identify Disease Specific Pathways

  Journal article

  Filer A. et al, (2015), PLOS ONE, 10, e0120917 - e0120917

• Stromal Cells in Chronic Inflammation and Tertiary Lymphoid Organ Formation

  Journal article

  Buckley CD. et al, (2015), Annual Review of Immunology, 33, 715 - 745

• Ultrasound-guided synovial biopsy: a safe, well-tolerated and reliable technique for obtaining high-quality synovial tissue from both large and small joints in early arthritis patients.

  Journal article

  Kelly S. et al, (2015), Ann Rheum Dis, 74, 611 - 617

• TNFα regulates cortisol metabolism in vivo in patients with inflammatory arthritis.

  Journal article

  Nanus DE. et al, (2015), Ann Rheum Dis, 74, 464 - 469

• Rheumatoid arthritis: The two faces of Rsk2 in hyperplastic disease

  Journal article

  Falconer J. and Buckley CD., (2015), Nature Reviews Rheumatology, 11, 203 - 205

• Podoplanin negatively regulates CD4+ effector T cell responses

  Journal article

  Peters A. et al, (2015), Journal of Clinical Investigation, 125, 129 - 140

• Genetic Deletion of the Stromal Cell Marker CD248 (Endosialin) Protects against the Development of Renal Fibrosis

  Journal article

  Smith SW. et al, (2015), Nephron, 131, 265 - 277

• The biology of IL-23 and IL-17 and their therapeutic targeting in rheumatic diseases.

  Journal article

  Sherlock JP. et al, (2015), Curr Opin Rheumatol, 27, 71 - 75

• Predictors of time to revision and clinical outcomes following revision of metal-on-metal hip replacements for adverse reaction to metal debris.

  Journal article

  Matharu GS. et al, (2014), Bone Joint J, 96-B, 1600 - 1609

• CLEC-2 expression is maintained on activated platelets and on platelet microparticles

  Journal article

  Gitz E. et al, (2014), Blood, 124, 2262 - 2270

• Nonclassical Ly6C− Monocytes Drive the Development of Inflammatory Arthritis in Mice

  Journal article

  Misharin AV. et al, (2014), Cell Reports, 9, 591 - 604

• Association of circulating miR-223 and miR-16 with disease activity in patients with early rheumatoid arthritis

  Journal article

  Filková M. et al, (2014), Annals of the Rheumatic Diseases, 73, 1898 - 1904

• A Differential Role for CD248 (Endosialin) in PDGF-Mediated Skeletal Muscle Angiogenesis

  Journal article

  Naylor AJ. et al, (2014), PLoS ONE, 9, e107146 - e107146

• Resolving Salmonella infection reveals dynamic and persisting changes in murine bone marrow progenitor cell phenotype and function.

  Journal article

  Ross EA. et al, (2014), Eur J Immunol, 44, 2318 - 2330

• Stroma: Fertile soil for inflammation

  Journal article

  Patel R. et al, (2014), Best Practice & Research Clinical Rheumatology, 28, 565 - 576

• Diagnostic outcomes associated with ankle synovitis in early inflammatory arthritis: a cohort study.

  Journal article

  Abhishek A. et al, (2014), Clin Exp Rheumatol, 32, 533 - 538

• Response to: 'The autoantibody repertoire in periodontitis: a role in the induction of autoimmunity to citrullinated proteins in rheumatoid arthritis? Antibodies against uncitrullinated peptides seem to occur prior to the antibodies to the corresponding citrullinated peptides' by Brink et al.

  Journal article

  de Pablo P. et al, (2014), Ann Rheum Dis, 73

• Evidence of NLRP3-inflammasome activation in rheumatoid arthritis (RA); genetic variants within the NLRP3-inflammasome complex in relation to susceptibility to RA and response to anti-TNF treatment

  Journal article

  Mathews RJ. et al, (2014), Annals of the Rheumatic Diseases, 73, 1202 - 1210

• CLEC-2 is required for development and maintenance of lymph nodes

  Journal article

  Benezech C. et al, (2014), Blood, 123, 3200 - 3207

• Proresolving Lipid Mediators and Mechanisms in the Resolution of Acute Inflammation

  Journal article

  Buckley CD. et al, (2014), Immunity, 40, 315 - 327

• The autoantibody repertoire in periodontitis: a role in the induction of autoimmunity to citrullinated proteins in rheumatoid arthritis?

  Journal article

  de Pablo P. et al, (2014), Ann Rheum Dis, 73, 580 - 586

• The critical role of interleukin-23 in spondyloarthropathy

  Journal article

  Sherlock JP. et al, (2014), MOLECULAR IMMUNOLOGY, 57, 38 - 43

• Analysis of the effects of stromal cells on the migration of lymphocytes into and through inflamed tissue using 3-D culture models

  Journal article

  Jeffery HC. et al, (2013), Journal of Immunological Methods, 400-401, 45 - 57

• Crosstalk Between Mesenchymal Stem Cells and Endothelial Cells Leads to Downregulation of Cytokine-Induced Leukocyte Recruitment

  Journal article

  Thin Luu N. et al, (2013), STEM CELLS, 31, 2690 - 2702

• The Impact of Inflammation on Metabolomic Profiles in Patients With Arthritis

  Journal article

  Young SP. et al, (2013), Arthritis & Rheumatism, 65, 2015 - 2023

• Identification of the Tyrosine-Protein Phosphatase Non-Receptor Type 2 as a Rheumatoid Arthritis Susceptibility Locus in Europeans

  Journal article

  Cobb JE. et al, (2013), PLoS ONE, 8, e66456 - e66456

• Metabolic profiling predicts response to anti-tumor necrosis factor α therapy in patients with rheumatoid arthritis.

  Journal article

  Kapoor SR. et al, (2013), Arthritis Rheum, 65, 1448 - 1456

• Right target, right place, right time: how understandings of pathogenic mechanisms are informing the treatment of rheumatic diseases

  Journal article

  Raza K. and Buckley CD., (2013), Current Opinion in Pharmacology, 13, 402 - 404

• The Role of Platelet-Endothelial Cell Adhesion Molecule-1 in Atheroma Formation Varies Depending on the Site-Specific Hemodynamic Environment

  Journal article

  Harrison M. et al, (2013), Arteriosclerosis, Thrombosis, and Vascular Biology, 33, 694 - 701

• Measuring the specific activity of the protein tyrosine phosphatase Lyp

  Journal article

  Bayley R. et al, (2013), Journal of Immunological Methods, 388, 33 - 39

• The role of stromal cells in the persistence of chronic inflammation

  Journal article

  Naylor AJ. et al, (2013), Clinical & Experimental Immunology, 171, 30 - 35

• Curbing Inflammation

  Journal article

  Landis RC. et al, (2013), International Journal of Inflammation, 2013, 1 - 3

• Differential expression of CD148 on leukocyte subsets in inflammatory arthritis

  Journal article

  Dave RK. et al, (2013), Arthritis Research & Therapy, 15, R108 - R108

• Lymphoid aggregates that resemble tertiary lymphoid organs define a specific pathological subset in metal-on-metal hip replacements.

  Journal article

  Mittal S. et al, (2013), PLoS One, 8

• The role of non-hematopoietic stromal cells in the persistence of inflammation

  Journal article

  Barone F. et al, (2013), Frontiers in Immunology, 3

• What can rheumatologists learn from translational cancer therapy?

  Journal article

  Sherlock JP. et al, (2013), Arthritis Res Ther, 15

• High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis.

  Journal article

  Eyre S. et al, (2012), Nat Genet, 44, 1336 - 1340

• The resolution of inflammation

  Journal article

  Buckley CD. et al, (2012), Nature Reviews Immunology, 13, 59 - 66

• The mesenchymal stem cell marker CD248 (endosialin) is a negative regulator of bone formation in mice

  Journal article

  Naylor AJ. et al, (2012), Arthritis & Rheumatism, 64, 3334 - 3343

• Pericytes promote selective vessel regression to regulate vascular patterning

  Journal article

  Simonavicius N. et al, (2012), Blood, 120, 1516 - 1527

• Association between bone mineral density and C-reactive protein in a large population-based sample

  Journal article

  de Pablo P. et al, (2012), Arthritis & Rheumatism, 64, 2624 - 2631

• Inflammatory regulation of glucocorticoid metabolism in mesenchymal stromal cells.

  Journal article

  Ahasan MM. et al, (2012), Arthritis Rheum, 64, 2404 - 2413

• IL-23 induces spondyloarthropathy by acting on ROR-γt+ CD3+CD4-CD8- entheseal resident T cells.

  Journal article

  Sherlock JP. et al, (2012), Nat Med, 18, 1069 - 1076

• Modulation of functional responses of endothelial cells linked to angiogenesis and inflammation by shear stress: Differential effects of the mechanotransducer CD31

  Journal article

  Glen K. et al, (2012), Journal of Cellular Physiology, 227, 2710 - 2721

• EULAR recommendations for terminology and research in individuals at risk of rheumatoid arthritis: report from the Study Group for Risk Factors for Rheumatoid Arthritis

  Journal article

  Gerlag DM. et al, (2012), Annals of the Rheumatic Diseases, 71, 638 - 641

• Tissue stroma as a regulator of leukocyte recruitment in inflammation

  Journal article

  McGettrick HM. et al, (2012), Journal of Leukocyte Biology, 91, 385 - 400

• CD248 expression on mesenchymal stromal cells is required for post-natal and infection-dependent thymus remodelling and regeneration

  Journal article

  Lax S. et al, (2012), FEBS Open Bio, 2, 187 - 190

• Synovial DKK1 expression is regulated by local glucocorticoid metabolism in inflammatory arthritis

  Journal article

  Hardy R. et al, (2012), Arthritis Research & Therapy, 14, R226 - R226

• The development of anti-cytokine agents for rheumatoid arthritis

  Chapter

  Raza K. et al, (2012), Development of Therapeutic Agents Handbook, 881 - 986

• Fibroblastic Reticular Cells From Lymph Nodes Attenuate T Cell Expansion by Producing Nitric Oxide

  Journal article

  Siegert S. et al, (2011), PLoS ONE, 6, e27618 - e27618

• Cytokine mRNA profiling identifies B cells as a major source of RANKL in rheumatoid arthritis

  Journal article

  Yeo L. et al, (2011), Annals of the Rheumatic Diseases, 70, 2022 - 2028

• The response of T cells to interleukin-6 is differentially regulated by the microenvironment of the rheumatoid synovial fluid and tissue

  Journal article

  Hidalgo E. et al, (2011), Arthritis & Rheumatism, 63, 3284 - 3293

• 57 Mesenchymal stem cells inhibit recruitment of flowing neutrophils and lymphocytes by endothelial cells: roles of interleukin-6 and transforming growth factor- 

  Conference paper

  Luu NT. et al, (2011), Heart, 97, e7 - e7

• A BAFF/APRIL-dependent TLR3-stimulated pathway enhances the capacity of rheumatoid synovial fibroblasts to induce AID expression and Ig class-switching in B cells

  Journal article

  Bombardieri M. et al, (2011), Annals of the Rheumatic Diseases, 70, 1857 - 1865

• Delays in assessment of patients with rheumatoid arthritis: variations across Europe

  Journal article

  Raza K. et al, (2011), Annals of the Rheumatic Diseases, 70, 1822 - 1825

• The stromal cell antigen CD248 (endosialin) is expressed on naive CD8+ human T cells and regulates proliferation.

  Journal article

  Hardie DL. et al, (2011), Immunology, 133, 288 - 295

• Why does chronic inflammation persist: An unexpected role for fibroblasts

  Journal article

  Buckley CD., (2011), Immunology Letters, 138, 12 - 14

• CD248+ stromal cells are associated with progressive chronic kidney disease

  Journal article

  Smith SW. et al, (2011), Kidney International, 80, 199 - 207

• Performance of the 2010 ACR/EULAR criteria for rheumatoid arthritis: comparison with 1987 ACR criteria in a very early synovitis cohort.

  Journal article

  Cader MZ. et al, (2011), Ann Rheum Dis, 70, 949 - 955

• Association of T-Zone Reticular Networks and Conduits with Ectopic Lymphoid Tissues in Mice and Humans

  Journal article

  Link A. et al, (2011), The American Journal of Pathology, 178, 1662 - 1675

• Utility of ultrasound joint counts in the prediction of rheumatoid arthritis in patients with very early synovitis.

  Journal article

  Filer A. et al, (2011), Ann Rheum Dis, 70, 500 - 507

• Genome-wide association study of genetic predictors of anti-tumor necrosis factor treatment efficacy in rheumatoid arthritis identifies associations with polymorphisms at seven loci

  Journal article

  Plant D. et al, (2011), Arthritis & Rheumatism, 63, 645 - 653

• Altered expression of microRNA-203 in rheumatoid arthritis synovial fibroblasts and its role in fibroblast activation

  Journal article

  Stanczyk J. et al, (2011), Arthritis & Rheumatism, 63, 373 - 381

• Stromal cells differentially regulate neutrophil and lymphocyte recruitment through the endothelium

  Journal article

  McGettrick HM. et al, (2010), Immunology, 131, 357 - 370

• A distinct subset of podoplanin (gp38) expressing F4/80+ macrophages mediate phagocytosis and are induced following zymosan peritonitis

  Journal article

  Hou TZ. et al, (2010), FEBS Letters, 584, 3955 - 3961

• The relationship between the presence of anti-cyclic citrullinated peptide antibodies and clinical phenotype in very early rheumatoid arthritis.

  Journal article

  Cader MZ. et al, (2010), BMC Musculoskelet Disord, 11

• Critical role of Src-Syk-PLC 2 signaling in megakaryocyte migration and thrombopoiesis

  Journal article

  Mazharian A. et al, (2010), Blood, 116, 793 - 800

• Investigation of potential non-HLA rheumatoid arthritis susceptibility loci in a European cohort increases the evidence for nine markers

  Journal article

  Plant D. et al, (2010), Annals of the Rheumatic Diseases, 69, 1548 - 1553

• The pericyte and stromal cell marker CD248 (endosialin) is required for efficient lymph node expansion

  Journal article

  Lax S. et al, (2010), European Journal of Immunology, 40, 1884 - 1889

• Synergistic induction of local glucocorticoid generation by inflammatory cytokines and glucocorticoids: implications for inflammation associated bone loss.

  Journal article

  Kaur K. et al, (2010), Ann Rheum Dis, 69, 1185 - 1190

• The influence of ethnicity on the extent of, and reasons underlying, delay in general practitioner consultation in patients with RA

  Journal article

  Kumar K. et al, (2010), Rheumatology, 49, 1005 - 1012

• Cytokines and Inflammatory Mediators [30-39]: 30. The LPS Stimulated Production of Interleukin-10 is not Associated with -819C/T and -592C/A Promoter Polymorphisms in Healthy Indian Subjects

  Conference paper

  Shukla S. et al, (2010), Rheumatology, 49, i45 - i48

• Distinct Types of Fibrocyte Can Differentiate from Mononuclear Cells in the Presence and Absence of Serum

  Journal article

  Curnow SJ. et al, (2010), PLoS ONE, 5, e9730 - e9730

• Anti-modified citrullinated vimentin (MCV) antibodies in patients with very early synovitis

  Journal article

  Raza K. et al, (2010), Annals of the Rheumatic Diseases, 69, 627 - 628

• Splenic stromal cells mediate IL-7 independent adult lymphoid tissue inducer cell survival

  Journal article

  Hou TZ. et al, (2010), European Journal of Immunology, 40, 359 - 365

• Rheumatoid synovial fluid interleukin-17-producing CD4 T cells have abundant tumor necrosis factor-alpha co-expression, but little interleukin-22 and interleukin-23R expression

  Journal article

  Church LD. et al, (2010), Arthritis Research & Therapy, 12, R184 - R184

• Monocytes/macrophages express chemokine receptor CCR9 in rheumatoid arthritis and CCL25 stimulates their differentiation

  Journal article

  Schmutz C. et al, (2010), Arthritis Research & Therapy, 12, R161 - R161

• Epidemiology of joint disorders in Parkinson’s disease and their impact on health status

  Journal article

  Natalwala A. et al, (2009), Journal of Clinical Neuroscience, 16, 1382 - 1383

• Decreased TNF-α synthesis by macrophages restricts cutaneous immunosurveillance by memory CD4 + T cells during aging

  Journal article

  Agius E. et al, (2009), The Journal of Experimental Medicine, 206, 1929 - 1940

• The porin OmpD from nontyphoidal Salmonella is a key target for a protective B1b cell antibody response

  Journal article

  Gil-Cruz C. et al, (2009), Proceedings of the National Academy of Sciences, 106, 9803 - 9808

• CD151 Regulates Tumorigenesis by Modulating the Communication between Tumor Cells and Endothelium

  Journal article

  Sadej R. et al, (2009), Molecular Cancer Research, 7, 787 - 798

• Galectin 3 induces a distinctive pattern of cytokine and chemokine production in rheumatoid synovial fibroblasts via selective signaling pathways

  Journal article

  Filer A. et al, (2009), Arthritis & Rheumatism, 60, 1604 - 1614

• A HaemAtlas: characterizing gene expression in differentiated human blood cells

  Journal article

  Watkins NA. et al, (2009), Blood, 113, e1 - e9

• Periodontitis in systemic rheumatic diseases

  Journal article

  de Pablo P. et al, (2009), Nature Reviews Rheumatology, 5, 218 - 224

• Investigation of genetic variants within candidate genes of the TNFRSF1B signalling pathway on the response to anti-TNF agents in a UK cohort of rheumatoid arthritis patients

  Journal article

  Bowes JD. et al, (2009), Pharmacogenetics and Genomics, 19, 319 - 323

• Mesenchymal stem cells: the fibroblasts' new clothes?

  Journal article

  Haniffa MA. et al, (2009), Haematologica, 94, 258 - 263

• Liver Myofibroblasts Regulate Infiltration and Positioning of Lymphocytes in Human Liver

  Journal article

  Holt AP. et al, (2009), Gastroenterology, 136, 705 - 714

• Fibroblasts from different sites may promote or inhibit recruitment of flowing lymphocytes by endothelial cells

  Journal article

  McGettrick HM. et al, (2009), European Journal of Immunology, 39, 113 - 125

• Immune Interactions in Hepatic Fibrosis

  Journal article

  Holt AP. et al, (2008), Clinics in Liver Disease, 12, 861 - 882

• Direct observations of the kinetics of migrating T cells suggest active retention by endothelial cells with continual bidirectional migration

  Journal article

  McGettrick HM. et al, (2008), Journal of Leukocyte Biology, 85, 98 - 107

• Selective accumulation of virus-specific CD8+ T cells with unique homing phenotype within the human bone marrow

  Journal article

  Palendira U. et al, (2008), Blood, 112, 3293 - 3302

• ‘I just thought it was normal aches and pains’: a qualitative study of decision-making processes in patients with early rheumatoid arthritis

  Journal article

  Sheppard J. et al, (2008), Rheumatology, 47, 1577 - 1582

• Local and systemic glucocorticoid metabolism in inflammatory arthritis.

  Journal article

  Hardy R. et al, (2008), Ann Rheum Dis, 67, 1204 - 1210

• Duffy antigen receptor for chemokines and CXCL5 are essential for the recruitment of neutrophils in a multicellular model of rheumatoid arthritis synovium

  Journal article

  Smith E. et al, (2008), Arthritis & Rheumatism, 58, 1968 - 1973

• Differential Effects of Bone Structural and Material Properties on Bone Competence in C57BL/6 and C3H/He Inbred Strains of Mice

  Conference paper

  Voide R. et al, (2008), Calcified Tissue International, 83, 61 - 69

• A Novel Role for PECAM-1 (CD31) in Regulating Haematopoietic Progenitor Cell Compartmentalization between the Peripheral Blood and Bone Marrow

  Journal article

  Ross EA. et al, (2008), PLoS ONE, 3, e2338 - e2338

• A role for the integrin  6 1 in the differential distribution of CD4 and CD8 T-cell subsets within the rheumatoid synovium

  Journal article

  Haworth O. et al, (2008), Rheumatology, 47, 1329 - 1334

• Fibroblasts as novel therapeutic targets in chronic inflammation

  Journal article

  Flavell SJ. et al, (2008), British Journal of Pharmacology, 153, S241 - S246

• Mediation of the proinflammatory cytokine response in rheumatoid arthritis and spondylarthritis by interactions between fibroblast-like synoviocytes and natural killer cells.

  Journal article

  Chan A. et al, (2008), Arthritis Rheum, 58, 707 - 717

• Beliefs about medicines in patients with rheumatoid arthritis and systemic lupus erythematosus: a comparison between patients of South Asian and White British origin

  Journal article

  Kumar K. et al, (2008), Rheumatology, 47, 690 - 697

• Glucocorticoid treatment inhibits annexin-1 expression in rheumatoid arthritis CD4+ T cells

  Journal article

  D'Acquisto F. et al, (2008), Rheumatology, 47, 636 - 639

• Differential regulation of nuclear and mitochondrial Bcl-2 in T cell apoptosis

  Journal article

  Scheel-Toellner D. et al, (2008), Apoptosis, 13, 109 - 117

• Prolonged, granulocyte–macrophage colony-stimulating factor-dependent, neutrophil survival following rheumatoid synovial fibroblast activation by IL-17 and TNFalpha

  Journal article

  Parsonage G. et al, (2008), Arthritis Research & Therapy, 10, R47 - R47

• Physiology and Pathology of the musculoskeletal system

  Chapter

  Buckley C., (2008), Textbook of Orthopaedics Trauma and Rheumatology, 41 - 52

• Resolving the problem of persistence in the switch from acute to chronic inflammation

  Journal article

  Haworth O. and Buckley CD., (2007), Proceedings of the National Academy of Sciences, 104, 20647 - 20648

• Serum amyloid P and fibrosis in systemic sclerosis: Comment on the article by Tennent et al

  Journal article

  Pilling D. et al, (2007), Arthritis & Rheumatism, 56, 4229 - 4229

• Anti-collagen type II antibodies in patients with very early synovitis

  Journal article

  Raza K. et al, (2007), Annals of the Rheumatic Diseases, 67, 1354 - 1355

• Modulation of endothelial responses by the stromal microenvironment: effects on leucocyte recruitment

  Journal article

  McGettrick HM. et al, (2007), Biochemical Society Transactions, 35, 1161 - 1162

• CCL21 expression pattern of human secondary lymphoid organ stroma is conserved in inflammatory lesions with lymphoid neogenesis.

  Journal article

  Manzo A. et al, (2007), Am J Pathol, 171, 1549 - 1562

• Skin cancer in psoriatic arthritis treated with anti-TNF therapy

  Journal article

  Sheppard J. et al, (2007), Rheumatology, 46, 1622 - 1623

• CD248/Endosialin is dynamically expressed on a subset of stromal cells during lymphoid tissue development, splenic remodeling and repair

  Journal article

  Lax S. et al, (2007), FEBS Letters, 581, 3550 - 3556

• Delay in presentation to primary care physicians is the main reason why patients with rheumatoid arthritis are seen late by rheumatologists

  Journal article

  Kumar K. et al, (2007), Rheumatology, 46, 1438 - 1440

• A novel role for PECAM-1 in megakaryocytokinesis and recovery of platelet counts in thrombocytopenic mice

  Journal article

  Dhanjal TS. et al, (2007), Blood, 109, 4237 - 4244

• Resolution of inflammation: state of the art, definitions and terms

  Journal article

  Serhan CN. et al, (2007), The FASEB Journal, 21, 325 - 332

• CD molecules 2006--human cell differentiation molecules.

  Journal article

  Zola H. et al, (2007), J Immunol Methods, 319, 1 - 5

• Careers in clinical academic medicine: new opportunities or old threats?

  Journal article

  Buckley CD., (2007), Clinical Medicine, 7, 79 - 81

• Minimal regulation of platelet activity by PECAM-1

  Journal article

  Dhanjal TS. et al, (2007), Platelets, 18, 56 - 67

• Phototoxicity and fluorotoxicity combine to alter the behavior of neutrophils in fluorescence microscopy based flow adhesion assays

  Journal article

  Smith E. et al, (2006), Microscopy Research and Technique, 69, 875 - 884

• Annexin-1 modulates T-cell activation and differentiation

  Journal article

  D'Acquisto F. et al, (2006), Blood, 109, 1095 - 1102

• Treating very early rheumatoid arthritis

  Journal article

  Raza K. et al, (2006), Best Practice & Research Clinical Rheumatology, 20, 849 - 863

• “From bench to bedside and back again- emerging opportunities”

  Journal article

  Bresnihan B. and Buckley C., (2006), Best Practice & Research Clinical Rheumatology, 20, 827 - 828

• Targeting the stromal microenvironment in chronic inflammation

  Journal article

  FILER A. et al, (2006), Current Opinion in Pharmacology, 6, 393 - 400

• Chemokine- and adhesion-dependent survival of neutrophils after transmigration through cytokine-stimulated endothelium

  Journal article

  McGettrick HM., (2006), Journal of Leukocyte Biology, 79, 779 - 788

• Differential expression, function and response to inflammatory stimuli of 11beta-hydroxysteroid dehydrogenase type 1 in human fibroblasts: a mechanism for tissue-specific regulation of inflammation.

  Journal article

  Hardy RS. et al, (2006), Arthritis Res Ther, 8

• Angiogenesis and cell trafficking

  Chapter

  Buckley C. and Filer A., (2006), Rheumatoid arthritis: frontiers of pathogenesis and treatment 2nd edition, 157 - 172

• Identification of a phenotypically and functionally distinct population of long-lived neutrophils in a model of reverse endothelial migration

  Journal article

  Buckley CD., (2005), Journal of Leukocyte Biology, 79, 303 - 311

• CD molecules 2005: human cell differentiation molecules.

  Journal article

  Zola H. et al, (2005), Blood, 106, 3123 - 3126

• A novel mechanism of neutrophil recruitment in a coculture model of the rheumatoid synovium

  Journal article

  Lally F. et al, (2005), Arthritis & Rheumatism, 52, 3460 - 3469

• Generation and characterization of novel stromal specific antibodies

  Journal article

  HALDER S. et al, (2005), Cell Research, 15, 739 - 744

• Tonsillar homing of Epstein-Barr virus-specific CD8+ T cells and the virus-host balance

  Journal article

  Hislop AD., (2005), Journal of Clinical Investigation, 115, 2546 - 2555

• Some new, and not so new, anti-inflammatory targets

  Journal article

  (2005), Current Opinion in Pharmacology, 5, 394 - 397

• Report on antibodies submitted to the stromal cell section of HLDA8

  Journal article

  Buckley CD. et al, (2005), Cellular Immunology, 236, 29 - 41

• Treatment of early rheumatoid arthritis

  Journal article

  Raza K. et al, (2005), Therapy, 2, 659 - 668

• A panel of monoclonal antibodies recognizing GPI-anchored ADP-ribosyltransferase ART4, the carrier of the Dombrock blood group antigens

  Journal article

  Parusel I. et al, (2005), Cellular Immunology, 236, 59 - 65

• Endosialin (TEM1, CD248) is a marker of stromal fibroblasts and is not selectively expressed on tumour endothelium

  Journal article

  MacFadyen JR. et al, (2005), FEBS Letters, 579, 2569 - 2575

• Analysis of host response to bacterial infection using error model based gene expression microarray experiments

  Journal article

  Stekel DJ., (2005), Nucleic Acids Research, 33, e53 - e53

• A stromal address code defined by fibroblasts

  Journal article

  Parsonage G. et al, (2005), Trends in Immunology, 26, 150 - 156

• Endothelial cells, fibroblasts and vasculitis

  Journal article

  Buckley CD. et al, (2005), Rheumatology, 44, 860 - 863

• Stromal cells as new therapeutic targets in rheumatoid arthritis

  Journal article

  Haworth O. et al, (2005), Therapy, 2, 121 - 129

• The role of leukocyte-stromal interactions in chronic inflammatory joint disease

  Journal article

  Burman A. et al, (2005), Joint Bone Spine, 72, 10 - 16

• Defining a role for fibroblasts in the persistence of chronic inflammatory joint disease

  Journal article

  Buckley CD., (2004), Annals of the Rheumatic Diseases, 63, ii92 - ii95

• Detection of differentially expressed genes in synovial fibroblasts by restriction fragment differential display.

  Journal article

  Scaife S. et al, (2004), Rheumatology (Oxford), 43, 1346 - 1352

• Bayesian Variable Selection in Multinomial Probit Models to Identify Molecular Signatures of Disease Stage

  Journal article

  Sha N. et al, (2004), Biometrics, 60, 812 - 819

• The local physicochemical environment conditions the proinflammatory response of endothelial cells and thus modulates leukocyte recruitment

  Journal article

  Nash GB. et al, (2004), FEBS Letters, 569, 13 - 17

• Chemokines and Persistent Inflammation in Rheumatoid Arthritis: Hunting for Therapeutic Targets

  Journal article

  Filer A. et al, (2004), Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents, 3, 103 - 117

• Why do leucocytes accumulate within chronically inflamed joints?

  Journal article

  Buckley CD., (2003), Rheumatology, 42, 1433 - 1444

• Transendothelial migration confers a survival advantage to activated T lymphocytes: role of LFA-1/ICAM-1 interactions.

  Journal article

  Borthwick NJ. et al, (2003), Clin Exp Immunol, 134, 246 - 252

• CD31 Regulates Direction and Rate of Neutrophil Migration over and under Endothelial Cells

  Journal article

  Luu NT. et al, (2003), Journal of Vascular Research, 40, 467 - 479

• Global gene expression profiles in fibroblasts from synovial,skin and lymphoid tissue reveals distinct cytokine and chemokine expression patterns

  Journal article

  Parsonage G. et al, (2003), Thrombosis and Haemostasis

• Rheumatoid fibroblast-like synoviocytes overexpress the chemokine stromal cell-derived factor 1 (CXCL12), which supports distinct patterns and rates of CD4+ and CD8+ T cell migration within synovial tissue

  Journal article

  Bradfield PF. et al, (2003), Arthritis & Rheumatism, 48, 2472 - 2482

• Why does chronic inflammatory joint disease persist?

  Journal article

  Buckley CD., (2003), Clinical Medicine, 3, 361 - 366

• The peripheral generation of CD4+ CD25+ regulatory T cells

  Journal article

  Akbar AN. et al, (2003), Immunology, 109, 319 - 325

• Ultrasound guidance allows accurate needle placement and aspiration from small joints in patients with early inflammatory arthritis

  Journal article

  Raza K., (2003), Rheumatology, 42, 976 - 979

• Why does inflammation persist: a dominant role for the stromal microenvironment?

  Journal article

  Douglas MR. et al, (2002), Expert Reviews in Molecular Medicine, 4

• Identification of synovium-specific homing peptides by in vivo phage display selection

  Journal article

  Lee L. et al, (2002), Arthritis & Rheumatism, 46, 2109 - 2120

• Apoptosis disables CD31-mediated cell detachment from phagocytes promoting binding and engulfment

  Journal article

  Brown S. et al, (2002), Nature, 418, 200 - 203

• Characterization of four CD18 mutants in leucocyte adhesion deficient (LAD) patients with differential capacities to support expression and function of the CD11/CD18 integrins LFA-1, Mac-1 and p150,95.

  Journal article

  Shaw JM. et al, (2001), Clin Exp Immunol, 126, 311 - 318

• Ectopic expression of the B cell-attracting chemokine BCA-1 (CXCL13) on endothelial cells and within lymphoid follicles contributes to the establishment of germinal center-like structures in Sj�gren's syndrome

  Journal article

  Amft N. et al, (2001), Arthritis & Rheumatism, 44, 2633 - 2641

• CD antigens 2001.

  Journal article

  Mason D. et al, (2001), Cell Immunol, 211, 81 - 85

• Fibroblasts regulate the switch from acute resolving to chronic persistent inflammation

  Journal article

  Buckley CD. et al, (2001), Trends in Immunology, 22, 199 - 204

• Sticky moments with sticky molecules

  Journal article

  Buckley CD. and Simmons DL., (2000), Immunology Today, 21, 601 - 603

• The Small Gtpase, Rap1, Mediates Cd31-Induced Integrin Adhesion

  Journal article

  Reedquist KA. et al, (2000), The Journal of Cell Biology, 148, 1151 - 1158

• Differential association of cytoplasmic signalling molecules SHP-1, SHP-2, SHIP and phospholipase C-γ1 with PECAM-1/CD31

  Journal article

  Pumphrey NJ. et al, (1999), FEBS Letters, 450, 77 - 83

• The Myeloid-specific Sialic Acid-binding Receptor, CD33, Associates with the Protein-tyrosine Phosphatases, SHP-1 and SHP-2

  Journal article

  Taylor VC. et al, (1999), Journal of Biological Chemistry, 274, 11505 - 11512

• Interferon-β mediates stromal cell rescue of T cells from apoptosis

  Journal article

  Pilling D. et al, (1999), European Journal of Immunology, 29, 1041 - 1050

• RGD peptides induce apoptosis by direct caspase-3 activation

  Journal article

  Buckley CD. et al, (1999), Nature, 397, 534 - 539

• Localized bowel vasculitis: Postoperative cyclophosphamide or not?

  Journal article

  Raza K. et al, (1999), Arthritis & Rheumatism, 42, 182 - 185

• Type I interferons inhibit the resolution of chronic inflammation

  Chapter

  Buckley C. et al, (1999), Programmed Cell Death in Animals and Plants Cell death in health and disease, 277 - 288

• The role of the cysteine-rich region of the β2 integrin subunit in the leukocyte function-associated antigen-1 (LFA-1, αLβ2, CD11a/CD18) heterodimer formation and ligand binding

  Journal article

  Douglass WA. et al, (1998), FEBS Letters, 440, 414 - 418

• Cell adhesion: More than just glue (Review)

  Journal article

  Buckley CD. et al, (1998), Molecular Membrane Biology, 15, 167 - 176

• Residues on both faces of the first immunoglobulin fold contribute to homophilic binding sites of PECAM-1/CD31.

  Journal article

  Newton JP. et al, (1997), J Biol Chem, 272, 20555 - 20563

• Science, medicine, and the future: Treatment of rheumatoid arthritis

  Journal article

  Buckley CD., (1997), BMJ, 315, 236 - 238

• Cross-talk between cell adhesion molecules regulates the migration velocity of neutrophils

  Journal article

  Rainger GE. et al, (1997), Current Biology, 7, 316 - 325

• Role of ligands in the activation of LFA-1

  Journal article

  Buckley CD. et al, (1997), European Journal of Immunology, 27, 957 - 962

• A distinct profile of six soluble adhesion molecules (ICAM-1, ICAM-3, VCAM-1, E-selectin, L-selectin and P-selectin) in rheumatoid arthritis.

  Journal article

  Littler AJ. et al, (1997), Br J Rheumatol, 36, 164 - 169

• Identification of alpha v beta 3 as a heterotypic ligand for CD31/PECAM-1

  Journal article

  Buckley C. et al, (1996), Journal of Cell Science, 109, 437 - 445

• Prolonged half-life of verapamil in a case of overdose: implications for therapy.

  Journal article

  Buckley CD. and Aronson JK., (1995), Br J Clin Pharmacol, 39, 680 - 683

• Analysis of the Binding Site on Intercellular Adhesion Molecule 3 for the Leukocyte Integrin Lymphocyte Function-associated Antigen 1

  Journal article

  Holness CL. et al, (1995), Journal of Biological Chemistry, 270, 877 - 884

• Stimulation of Adenylate Cyclase Activity in Rat Thymocytes in Vitro by 3,5,3′-Triiodothyronine*

  Journal article

  SEGAL JOSEPH. et al, (1985), Endocrinology, 116, 2036 - 2043

• Cell damage by viruses, toxins and complement: common features of pore formation and its inhibition by Ca2+

  Journal article

  Buckley C., (1985), Biochemical Society. Symposia, 50, 247 - 264

• Identification of a transitional fibroblast functional phenotype in very early rheumatoid arthritis

  Journal article

  Filer A. et al, Annals of Rheumatic Diseases

• Stromal cell markers are differentially expressed in the synovial tissue of patients with early arthritis

  Journal article

  Turner J. et al, PLoS ONE

• Pathologically expanded ‘peripheral’ B cell-helper T cells in rheumatoid arthritis

  Journal article

  Buckley C., Nature

• Why should rheumatologists care about fibroblasts?

  Journal article

  Buckley CD., Rheumatology, kew289 - kew289

• Bimodal Expansion of the Lymphatic Vessels Is Regulated by the Sequential Expression of IL-7 and Lymphotoxin α1β2 in Newly Formed Tertiary Lymphoid Structures

  Journal article

  Nayar S. et al, Journal of Immunology

• BIOMARKERS OF AUTOIMMUNE AND/OR CHRONIC DISEASES ASSOCIATED WITH JOINT INFLAMMATION

  Other

  Scheel-Toellner D. et al

• Thymic function is maintained during Salmonella-induced atrophy and recovery

  Journal article

  Ross EA. et al, Journal of Immunology, 189, 4266 - 4274

• Inducible tertiary lymphoid structures, autoimmunity, and exocrine dysfunction in a novel model of salivary gland inflammation in C57BL/6 mice

  Journal article

  Buckley C. et al, Journal of Immunology, 189, 3767 - 3776

• Fibroblasts as therapeutic targets in rheumatoid arthritis and cancer

  Journal article

  Juarez M. et al, Swiss Medical Weekly

• CD31 Is Required on CD4(+) T Cells To Promote T Cell Survival during Salmonella Infection

  Journal article

  Ross E. et al, Journal of Immunology, 187, 1553 - 1565

• Prostaglandin D-2 Regulates CD4(+) Memory T Cell Trafficking across Blood Vascular Endothelium and Primes These Cells for Clearance across Lymphatic Endothelium

  Journal article

  Ahmed S. et al, Journal of Immunology, 187, 1432 - 1439

• Neutrophils live on a two-way street.

  Journal article

  Mulero V. et al, Journal of Leukocyte Biology, 89, 645 - 7

• Smoke exposure as a determinant of auto-antibody titre in AATD and COPD.

  Journal article

  Turner A. et al, European Respiratory Journal, 37, 32 - 38

• Influence of stromal cells on lymphocyte adhesion and migration on endothelial cells

  Journal article

  McGettrick H. et al, Methods in molecular biology, 616, 49 - 68

• Does time matter in the management of rheumatoid arthritis?

  Chapter

  De Pablo P. et al, Horizons in medicine 21, 21

• Platelet endothelial cell adhesion molecule (PECAM)-1 modulates SDF-1a/CXCR4 responses of hematopoietic stem cells

  Conference paper

  Ross E. et al, 450 - 450

• Ly49H(+) NK cells migrate to and protect splenic white pulp stroma from murine cytomegalovirus infection

  Journal article

  Bekiaris V. et al, Journal of Immunology, 180, 6768 - 6776

• The role of chemokines in leucocyte-stromal interactions in rheumatoid arthritis

  Journal article

  Filer A. et al, Frontiers in Bioscience, 13, 2674 - 85

• CD56bright human NK cells differentiate into CD56dim cells: role of contact with peripheral fibroblasts

  Journal article

  Chan A. et al, Journal of Immunology, 179, 89 - 94

• Targeting stromal cells in chronic inflammation

  Journal article

  Filer A. et al, Discovery medicine, 7, 20 - 6

• Minimal regulation of platelet activity by PECAM-1 (vol 18, pg 56, 2007)

  Journal article

  Dhanjal T. et al, Platelets, 18, 472 - 472

• Periarticular bone loss in arthritis: Role of synovial glucocorticoid generation

  Journal article

  Cooper M. et al, Journal of Bone and Mineral Research, 22, S178 - S178

• The local and sytemic effects of glucocorticoid generation in synovium

  Journal article

  Hardy R. et al, Journal of Bone and Mineral Research, 22, 1115 - 1116

• Activated human hepatic stellate cells promote lymphocyte adhesion to human sinusoidal endothelium under conditions replicating sinusoidal blood flow, and promote adhesion in an integrin and selectin dependent manner

  Conference paper

  Holt A. et al

• Activated human hepatic stellate cells promote lymphocyte adhesion to sinusoidal endothelium under flow, and accelerate lymphocyte chemotaxis in an IFNgamma-dependent manner

  Conference paper

  Holt A. et al

• Activated human hepatic stellate cells increase lymphocyte recruitment through hepatic sinusoidal endothelium and promote lymphocyte chemotaxis and transmigration

  Conference paper

  Holt A. et al

• Detailed analysis of intrahepatic CD8 T cells in the normal and hepatitis C-infected liver reveals differences in specific populations of memory cells with distinct homing phenotypes

  Journal article

  Heydtmann M. et al, Journal of Immunology, 177, 729 - 738

• Differential leucocyte subset survival mediated by synovial, bone marrow and skin fibroblasts in rheumatoid arthritis: site specific versus activation dependent survival of T cells and neutrophils

  Journal article

  Filer A. et al, Arthritis & Rheumatism, 54, 2096 - 2108

• The Assessment of T-Cell Apoptosis in Synovial Fluid

  Chapter

  Raza K. et al, Methods in Molecular Medicine: Arthritis Research, 136, 117 - 38

• Differential Induction of Fibroblast 11Beta-Hydroxysteroid Dehydrogenase Type 1: A Mechanism for Tissue Specific Regulation of Inflammation

  Conference paper

  No Value NV. et al, P2 - 109

• An in vitro model for analysing neutrophil migration into and away from the sub-endothelial space:: Roles of flow and CD31

  Journal article

  Chakravorty SJ. et al, Biorheology, 43, 71 - 82

• The functional consequences of local glucocorticoid metabolism in synovial fibroblasts

  Conference paper

  No Value NV. et al, P742 - P742

• Activated Human Hepatic Stellate Cells (AHSC) Promote Lymphocyte Adhesion to Sinusoidal Endothelium under Flow and Accelerate Lymphocyte Chemotaxis in an IFNg Dependent Manner

  Journal article

  Holt A. et al, Hepatology, 44, 1335a - 1335a

• Cell adhesion molecules - conversational signallers

  Chapter

  Douglas M. et al, Encyclopaedia of BioMedical Engineering

• Platelet Endothelial Cell Adhesion Molecule (PECAM)-1 modulates SDF-1alpha/CXCR4 responses of hematopoietic stem cells

  Conference paper

  Ross E. et al

• Synovial fluid Leukocyte Apoptosis is inhibited in Patients with Very Early Rheumatoid Arthritis

  Conference paper

  Raza K. et al, i37 - i37

• Synovial fluid leukocyte apoptosis is inhibited in patients with very early rheumatoid arthritis

  Journal article

  Raza K. et al, Arthritis Research & Therapy, 8

• Interaction between integrin α9β1 and Vascular Cell Adhesion Molecule-1 (VCAM-1) inhibits neutrophil apoptosis: cross-talk between integrin and cytokine signalling pathways

  Journal article

  Ross E. et al, Blood, 107, 1178 - 1183

• Early rheumatoid arthritis is characterised by a distinct and transient synovial fluid cytokine profile of T cell and stromal cell origin

  Journal article

  Raza K. et al, Arthritis Research & Therapy, 7, R784 - R795

• CCR7+ memory CD8 T cells in normal and chronic hepatitis C infected liver

  Conference paper

  Heydtmann M. et al

• Predictive value of antibodies to cyclic citrullinated peptide in patients with very early inflammatory arthritis

  Journal article

  Raza K. et al, The Journal of Rheumatology, 32, 231 - 8

• A chemokine-dependent stromal induction mechanism for aberrant lymphocyte accumulation and compromisd lymphatic return in rheumatoid arthritis

  Journal article

  Burman A. et al, Journal of Immunology, 174, 1693 - 700

• Activated HSC may drive chronic inflammation by promoting the recruitment and survival of highly differentiated CD4+ lymphocytes

  Conference paper

  Holt A. et al, 28 - 28

• Activated human hepatic stellate cells (HSC) perpetuate inflammation by maintaining survival of liver derived effector memory lymphocytes and promoting lymphocyte recruitment

  Conference paper

  Holt A. et al

• CCR7+ memory CD8 T cells in normal and chronic hepatitis C infected liver

  Conference paper

  Heydtmann M. et al, A45 - A45

• CCR7+ memory CD8 T cells in normal and chronic hepatitis C infected liver

  Conference paper

  Heydtmann M. et al, 158 - 159

• Hepatic stellate cells modulate the switch from acute to chronic inflammation by promoting lymphocyte recruitment, retention and survival

  Conference paper

  Holt A. et al, A328 - A328

• Inhibition of T cell apoptosis by IL–6 at sites of inflammation: direct and trans–signalling through the IL–6R are highly regulated on human T cells

  Conference paper

  Curnow S. et al, 3475 - 3475

• Transmigrated neutrophils down-regulate the expression of VCAM-1 on endothelial cells and inhibit the adhesion of flowing lymphocytes

  Journal article

  Stone PCW., Journal of Leukocyte Biology

• Chemokine receptors in the rheumatoid synovium upregulation of CXCR5

  Journal article

  Schmutz C. et al, Arthritis Research & Therapy, 7

• Topical glucocorticoid therapy directly induces up-regulation of functional CXCR4 on primed T lymphocytes in the aqueous humor of patients with uveitis

  Journal article

  Curnow S. et al, Journal of Immunology, 172, 7154 - 7161

• Biliary epithelial expression of VCAM-1 and CXCL12 co-operate in the persistence and survival of lymphocytes in PSC

  Journal article

  Eksteen J. et al, Hepatology, 40, 462A - 462A

• Biliary epithelial expression of VCAM-1 and CXCL12 co-operate in the persistence and survival of lymphocytes in PSC

  Conference paper

  Eksteen J. et al

• Biliary epithelial expression of VCAM-1 and CXCL12 cooperate in the persistence and survival of lymphocytes in PSC

  Conference paper

  Eksteen J. et al, 462A - 462A

• Biliary epithelial expression of VCAM-1 promotes the survival of lymphocytes in PSC

  Conference paper

  Eksteen J. et al, 32 - 32

• Defining a role for fibroblasts in the persistence of chronic inflammatory joint disease

  Journal article

  Buckley C. et al, Annals of the Rheumatic Diseases, 63, ii92 - ii95

• Human liver fibroblasts can promote inflammatory cell recruitment and retain lymphocytes through integrin-dependent pathways following liver injury

  Conference paper

  Holt A. et al

• Human liver fibroblasts can promote inflammatory cell recruitment, and retain lymphocytes through integrin-dependent pathways following liver injury

  Conference paper

  Holt A. et al

• Very early rheumatoid arthritis is characterised by a unique and transient T cell and stromal cytokine profile

  Journal article

  Raza K. et al, Rheumatology, 43, OP28 - OP28

• Very early rheumatoid arthritis is characterised by a unique and transient synovial cytokine profile of T cell and stromal origin

  Conference paper

  Raza K. et al, OP0067 - OP0067

• What is the role of fibroblasts in rheumatoid arthritis?

  Journal article

  Buckley C., Journal of the Royal College of Physicians of Edinburgh, 34, 65 - 6

• Activation requirements of human resting (CD45RA+) memory CD8+ T cells

  Conference paper

  Faint J. et al, 101 - 101

• Human hepatic myofibroblasts produce chemokines and adhesion molecules which promote the retention of lymphocytes during liver injury and fibrosis

  Conference paper

  Lalor P. et al, 781A - 781A

• Human hepatic myofibroblasts produce chemokines and adhesion molecules which promote the retention of lymphocytes during liver injury and fibrosis

  Conference paper

  Lalor P. et al

• Inhibition of Fibrocyte Differentiation by Serum Amyloid P1

  Journal article

  Pilling D. et al, Journal of Immunology, 171, 5537 - 46

• Phototoxic effects of Fluorescent dyes on cell behaviour in a flow-based assay system

  Conference paper

  Lally F. et al

• Phototoxic effects of fluorescent dyes on cell behaviour in a flow-based assay system

  Conference paper

  Smith E. et al

• Topical glucocorticoid therapy induces CXCR4 up-regulation on primed ocular lymphocytes

  Conference paper

  Wloka K. et al, S83 - S83

• Topical glucocorticoid therapy induces CXCR4 up-regulation on primed ocular lymphocytes in uveitis

  Conference paper

  Murray P. et al, 678 - 678

• Identification of antigen-specific lymphocytes, CCR7 expression and the role of apoptosis during resolving cutaneous inflammation

  Conference paper

  Buckley C., 299 - 299

• Aqueous humour induces CXCR4 upregulation during intraocular inflammation

  Journal article

  Wloka KM. et al, Chemokines 2002 International Meeting, El Escorial, Madrid, 5-12 May 2002

• Expression of the consitutive chemokines CXCL13 and CXCL12 contributes to the characteristic pattern of lymphocyte infiltration within Sjogren’s syndrome salivary glands

  Journal article

  Amft E. et al, Midland Rheumatalology Society

• Memory T cells constitute a subset of the human CD8+ CD45RA+ pool with distinct phenotypic and migratory characteristics

  Journal article

  Faint J. et al, Journal of Immunology, 167, 212 - 220

• Signaling through CD31 protects endothelial cells from apoptosis. PECAM-1/CD31: More than just glue

  Journal article

  Buckley C., Transplantation, 71, 343 - 344

• Mechanical and ’adhesive’ signals guiding neutrophil migration through endothelium

  Conference paper

  Luu N-T. et al

• Soluble Leukocyte - Endothelial Adhesion Molecules chapter 15

  Chapter

  Buckley C. et al, Physiology of Inflammation, 2001

• T cell adhesion molecules in autoimmunity

  Chapter

  Buckley C. et al, The Molecular Pathology of Autoimmune Diseases

• Persistent induction of the chemokine receptor CXCR4 by TGF-beta 1 on synovial T cells contributes to their accumulation within the rheumatoid synovium

  Journal article

  Buckley C. et al, Journal of Immunology, 165, 3423 - 9

• High cell density provides potent survival signals for resting T-cells

  Journal article

  Pilling D. et al, Cellular and molecular biology, 46, 163 - 74

• CD31 (PECAM-1) exists as a dimer and is heavily N-glycosylated

  Journal article

  Buckley C., Biochemical and Biophysical Research Communications, 26, 283 - 291

• Homophilic PECAM-1 (CD31) interactions prevent endothelial cell apoptosis but do not support cell spreading or migration

  Journal article

  Buckley C. et al, Journal of Cell Science, 112, 1989 - 1997

• Neutrophils sense flow-generated stress and direct their migration using anchorage through αVβ3-integrin

  Journal article

  Buckley C. et al, American Journal of Physiology, 276, 858 - 864

• Neutrophils rolling on immobilised platelets migrate into homotypic aggregates after activation

  Journal article

  Buckley C. et al, Thrombosis and Haemostasis, 79, 1177 - 1183

• Cell adhesion: a new target for therapy

  Journal article

  Buckley C., Molecular Medicine, 3, 449 - 456

• Mapping the homotypic binding sites in CD31 and the role of CD31 adhesion in the formation of interendothelial cell contacts

  Journal article

  Buckley C., European Journal of Immunology, 25, 459 - 465

Recent Publications

• Priming in response to pro-inflammatory cytokines is a feature of adult synovial but not dermal fibroblasts

  Journal article

  Crowley T. et al, (2017), Arthritis Research & Therapy, 19

• Detection and characterisation of bone destruction in murine rheumatoid arthritis using statistical shape models

  Journal article

  Brown JM. et al, (2017), Medical Image Analysis, 40, 30 - 43

• Genomic Responses of Mouse Synovial Fibroblasts During Tumor Necrosis Factor-Driven Arthritogenesis Greatly Mimic Those in Human Rheumatoid Arthritis.

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  Ntougkos E. et al, (2017), Arthritis Rheumatol, 69, 1588 - 1600

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