National Rheumatoid Arthritis Society webinar
Senior Clinical Research Fellow, Director of Clinical Research
Chris Buckley obtained his first degree in Biochemistry from the University of Oxford (1985) with subsequent undergraduate training in Medicine at the Royal Free Hospital, London (1990).
His postgraduate medical training was in General Medicine and Rheumatology at the Hammersmith Hospital, London (Professors Mark Walport and Dorian Haskard), and John Radcliffe Hospital, Oxford. He obtained a DPhil (arising from a Wellcome Trust Clinical Training Fellowship) with Professor John Bell and Dr David Simmons at the Institute Molecular Medicine, Oxford.
In 1996, funded by a Wellcome Trust Clinician Scientist Fellowship, he joined the Department of Rheumatology in Birmingham. In 2001, he was awarded an MRC Senior Clinical Fellowship and in 2002 became Arthritis Research UK Professor of Rheumatology. In 2012, he was appointed Director of the Birmingham NIHR Clinical Research Facility. And in May 2017, he was appointed as Kennedy Professor of Translational Rheumatology.
In this joint academic post as Director of Clinical Research at the Kennedy Institute in Oxford and Director of NIHR Infrastructure for Birmingham Heath Partners he will lead the Arthritis Therapy Acceleration Programme (A-TAP) which aims to deliver “stratified pathology” in a range of immune mediated inflammatory diseases in order to choose the right disease indication for the right drug.
This approach complements stratified medicine where the aim is to choose the right drug for the right patient. As part of the Stromal Cell group at the Kennedy, his laboratory explores the role of fibroblasts in driving disease progression and tissue tropism in Rheumatoid Arthritis..
Distinct tissue macrophage subsets regulate inflammation and provide a novel cellular and molecular mechanism for disease remission in rheumatoid arthritis
Alivernini S. et al, (2020), Nature Medicine
Cardiovascular risk factors and outcomes in early rheumatoid arthritis: a population-based study
Nikiphorou E. et al, (2020), Heart
Montero-Melendez T. et al, (2020), Nat Commun, 11
Oxidised metabolites of the omega-6 fatty acid linoleic acid activate dFOXO
Kwon SY. et al, (2020), Life Science Alliance
Synovial fibroblast positional identity controlled by inductive Notch signaling underlies pathologic damage in inflammatory arthritis
Wei K. et al, (2020), Nature