ADAM17-dependent proteolysis of L-selectin promotes early clonal expansion of cytotoxic T cells.
Mohammed RN. et al, (2019), Sci Rep, 9
Heparan Sulfate Proteoglycan Synthesis Is Dysregulated in Human Osteoarthritic Cartilage.
Chanalaris A. et al, (2019), Am J Pathol, 189, 632 - 647
LRP1 Controls TNF Release via the TIMP-3/ADAM17 Axis in Endotoxin-Activated Macrophages.
Schubert K. et al, (2019), J Immunol, 202, 1501 - 1509
Effect of Polarization and Chronic Inflammation on Macrophage Expression of Heparan Sulfate Proteoglycans and Biosynthesis Enzymes.
Swart M. and Troeberg L., (2019), J Histochem Cytochem, 67, 9 - 27
Heparan sulfate as a regulator of inflammation and immunity.
Collins LE. and Troeberg L., (2019), J Leukoc Biol, 105, 81 - 92
Increased TIMP-3 expression alters the cellular secretome through dual inhibition of the metalloprotease ADAM10 and ligand-binding of the LRP-1 receptor.
Scilabra SD. et al, (2018), Sci Rep, 8
Monoclonal antibodies targeting the disintegrin-like domain of ADAMDEC1 modulates the proteolytic activity and enables quantification of ADAMDEC1 protein in human plasma.
Lund J. et al, (2018), MAbs, 10, 118 - 128
Suramin Inhibits Osteoarthritic Cartilage Degradation by Increasing Extracellular Levels of Chondroprotective Tissue Inhibitor of Metalloproteinases 3.
Chanalaris A. et al, (2017), Mol Pharmacol, 92, 459 - 468
Inhibition of Shedding of Low-Density Lipoprotein Receptor-Related Protein 1 Reverses Cartilage Matrix Degradation in Osteoarthritis.
Yamamoto K. et al, (2017), Arthritis Rheumatol, 69, 1246 - 1256
ADAMTS and ADAM metalloproteinases in osteoarthritis - looking beyond the ‘usual suspects’
Yang CY. et al, (2017), Osteoarthritis Cartilage
MMP-13 is constitutively produced in human chondrocytes and co-endocytosed with ADAMTS-5 and TIMP-3 by the endocytic receptor LRP1.
Yamamoto K. et al, (2016), Matrix Biol, 56, 57 - 73
Engineered Tissue Inhibitor of Metalloproteinases-3 Variants Resistant to Endocytosis Have Prolonged Chondroprotective Activity.
Doherty CM. et al, (2016), J Biol Chem, 291, 22160 - 22172
Brief Report: JNK-2 Controls Aggrecan Degradation in Murine Articular Cartilage and the Development of Experimental Osteoarthritis.
Ismail HM. et al, (2016), Arthritis Rheumatol, 68, 1165 - 1171
Interleukin-1 Acts via the JNK-2 Signaling Pathway to Induce Aggrecan Degradation by Human Chondrocytes.
Ismail HM. et al, (2015), Arthritis Rheumatol, 67, 1826 - 1836
Extracellular regulation of metalloproteinases.
Yamamoto K. et al, (2015), Matrix Biol, 44-46, 255 - 263
Evidence for restricted reactivity of ADAMDEC1 with protein substrates and endogenous inhibitors.
Lund J. et al, (2015), J Biol Chem, 290, 6620 - 6629
Sulfated glycosaminoglycans control the extracellular trafficking and the activity of the metalloprotease inhibitor TIMP-3.
Troeberg L. et al, (2014), Chem Biol, 21, 1300 - 1309
Low density lipoprotein receptor-related protein 1 (LRP1)-mediated endocytic clearance of a disintegrin and metalloproteinase with thrombospondin motifs-4 (ADAMTS-4): functional differences of non-catalytic domains of ADAMTS-4 and ADAMTS-5 in LRP1 binding.
Yamamoto K. et al, (2014), J Biol Chem, 289, 6462 - 6474
LRP-1-mediated endocytosis regulates extracellular activity of ADAMTS-5 in articular cartilage.
Yamamoto K. et al, (2013), FASEB J, 27, 511 - 521