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Ca2+ and Zn2+ prevent antibody-dependent complement-induced permeability changes in tonsil lymphocytes and Lettre cells. Lactate dehydrogenase leaks out from Lettre cells at high complement:cell ratios, under which conditions higher concentrations of Ca2+ and Zn2+ are required for protection. Ca2+ and Zn2+ do not inhibit complement activation or C9 binding to Lettre cells, and prevent leakage through preformed lesions. It is concluded that the extent of complement-induced membrane damage depends on the concentration of extracellular Ca2+, and may be modulated by changes in extracellular Ca2+ or Zn2+.

Type

Journal article

Journal

Complement

Publication Date

1988

Volume

5

Pages

141 - 152

Keywords

Animals, Calcium, Cell Membrane Permeability, Cell Survival, Cells, Cultured, Complement C3, Complement C9, Complement Inactivator Proteins, Complement System Proteins, Hemolysis, Lymphocytes, Mice, Zinc