Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Hepatitis C virus (HCV) is a major global health burden accounting for around 170 million chronic infections worldwide. Since its discovery, which dates back to about 30 years ago, many details of the viral genome organization and the astonishing genetic diversity have been unveiled but, owing to the difficulty of culturing HCV in vitro and obtaining fully susceptible yet immunocompetent in vivo models, we are still a long way from the full comprehension of viral life cycle, host cell pathways facilitating or counteracting infection, pathogenetic mechanisms in vivo, and host defences. Here, we illustrate the viral life cycle into cells, describe the interplay between immune and genetic host factors shaping the course of infection, and provide details of the molecular approaches currently used to genotype, monitor replication in vivo, and study the emergence of drug-resistant viral variants.

Original publication

DOI

10.1016/j.cmi.2016.08.025

Type

Journal article

Journal

Clin Microbiol Infect

Publication Date

10/2016

Volume

22

Pages

826 - 832

Keywords

Broadly reactive neutralizing antibodies, Cell culture-derived HCV, Direct antiviral agents, Drug resistance, Genotype, Hepatitis C virus, Host response, Pathogenesis, Quantitative molecular assays, monitoring drug resistance, Antiviral Agents, Drug Resistance, Viral, Genotype, Hepacivirus, Hepatitis C, Host-Pathogen Interactions, Humans, Virulence Factors, Virus Replication