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The stable immunological synapse between a T cell and antigen-presenting cell coordinates migration and activation. Three-dimensional collagen gels transform this interaction into a series of transient hit-and-run encounters. Here we integrate these alternative modes of interaction in a model for primary T cell activation and effector function in vivo.

Type

Journal article

Journal

Curr Opin Immunol

Publication Date

06/2001

Volume

13

Pages

286 - 290

Keywords

Animals, Cell Movement, Extracellular Matrix, Humans, Lymphocyte Activation, Organ Specificity, T-Lymphocytes