Reprogramming T cells: the role of extracellular matrix in coordination of T cell activation and migration.
Dustin ML., de Fougerolles AR.
The stable immunological synapse between a T cell and antigen-presenting cell coordinates migration and activation. Three-dimensional collagen gels transform this interaction into a series of transient hit-and-run encounters. Here we integrate these alternative modes of interaction in a model for primary T cell activation and effector function in vivo.